Evidence map›Paper›PMID 41452929›Full record

ArticlePloS one2025

Biocompatibility and antimicrobial efficacy of iodine-supported titania nanotubes on 3D-printed Ti-6Al-4V implants.

Pariwat Taweekitikul, Abdul Azeez Abdu Aliyu, Nanthawan Jinakul, Amaraporn Wongrakpanich, Chedtha Puncreobutr, Jirapon Khamwannah, Boonrat Lohwongwatana, Saran Tantavisut

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In one paragraph

Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Pariwat TaweekitikulBiomedical Engineering Program, Faculty of Engineering, Chulalongkorn University, Bangkok, Thailand.ORCID https://orcid.org/0000-0002-8084-7986
Abdul Azeez Abdu AliyuM3D Laboratory, Advanced Materials Analysis Research Unit, Department of Metallurgical Engineering, Faculty of Engineering, Chulalongkorn University, Bangkok, Thailand.
Nanthawan JinakulDepartment of Microbiology, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand.
Amaraporn WongrakpanichDepartment of Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand.
Chedtha PuncreobutrM3D Laboratory, Advanced Materials Analysis Research Unit, Department of Metallurgical Engineering, Faculty of Engineering, Chulalongkorn University, Bangkok, Thailand.
Jirapon KhamwannahDepartment of Metallurgical Engineering, Faculty of Engineering, Chulalongkorn University, Bangkok, Thailand.
Boonrat LohwongwatanaM3D Laboratory, Advanced Materials Analysis Research Unit, Department of Metallurgical Engineering, Faculty of Engineering, Chulalongkorn University, Bangkok, Thailand.
Saran TantavisutBiomedical Engineering Research Center, Chulalongkorn University, Bangkok, Thailand.ORCID https://orcid.org/0000-0002-3767-4653

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Implant-associated infections (IAI) are a significant concern within the field of orthopedics. To develop an implant with antimicrobial properties, titania nanotubes (TNTs) supported with iodine were synthesized on 3D-printed Ti-6Al-4V implants using the electrochemical anodization (ECA) technique. This study aims to analyze the release profile of iodine and the antimicrobial efficacy and cytotoxicity of the iodine-supported TNT (I-TNTs) on the 3D-printed Ti-6Al-4V implant. 3D-printed Ti-6Al-4V samples were doped with six different iodine formulations, including four test groups containing TNT and two control groups without TNT. As printed 3D Ti-6Al-4V samples and TNTs samples without iodine were also utilized as control groups. In vitro assays were performed to assess the drug elution, cytotoxicity, and antimicrobial efficacy. All tested I-TNTs samples exhibited sustained iodine release over 28 days without an initial burst. Notably, the amount of iodine released from I-TNTs was significantly higher compared to the control group. TNTs with a higher aspect ratio (AR) and the ECA process using higher potassium iodide (KI) concentration were found to have better cumulative iodine release profiles. No cytotoxicity was observed when tested against the mouse calvaria-derived preosteoblast cell line (MC3T3-E1). The antibacterial property of the implant surface became evident within 24 hours, with complete inhibition of S. aureus and MRSA in I-TNTs samples. This innovative approach is an intriguing alternative for preventing infections on 3D-printed Ti-6Al-4V implants.

Indexed as

Anti-Bacterial AgentsAnti-Infective AgentsBiocompatible MaterialsIodineNanotubesPrinting, Three-DimensionalProstheses and ImplantsTitaniumAlloysAnimalsCell LineMaterials TestingMiceMicrobial Sensitivity TestsStaphylococcus aureusAlloysAnti-Bacterial AgentsAnti-Infective AgentsBiocompatible MaterialsIodineTitaniumtitanium alloy (TiAl6V4)titanium dioxide

Identifiers

PMID41452929
PMCPMC12742766

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.