ArticleAmerican journal of physiology. Endocrinology and metabolism2026
Global loss of selenocysteine lyase in mice drives lipid accumulation in brown adipocytes.
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Article in American journal of physiology. Endocrinology and metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
20 authors.
Briana K ShimadaPacific Biosciences Research Center, School of Ocean and Earth Science and Technology, University of Hawaii at Manoa, Honolulu, Hawaii, United States.ORCID 0000-0003-1521-6966
Ashley N Ogawa-WongDepartment of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii, United States.
Antonio G SoaresPacific Biosciences Research Center, School of Ocean and Earth Science and Technology, University of Hawaii at Manoa, Honolulu, Hawaii, United States.ORCID 0000-0001-5814-3475
Kayla A HallamPacific Biosciences Research Center, School of Ocean and Earth Science and Technology, University of Hawaii at Manoa, Honolulu, Hawaii, United States.ORCID 0000-0001-8211-3479
Princess J D SantiagoPacific Biosciences Research Center, School of Ocean and Earth Science and Technology, University of Hawaii at Manoa, Honolulu, Hawaii, United States.ORCID 0000-0001-9111-2531
Kaitlyn SaeluaPacific Biosciences Research Center, School of Ocean and Earth Science and Technology, University of Hawaii at Manoa, Honolulu, Hawaii, United States.
Kescher K Nakahara-AkitaPacific Biosciences Research Center, School of Ocean and Earth Science and Technology, University of Hawaii at Manoa, Honolulu, Hawaii, United States.ORCID 0009-0005-5627-4048
Daniel J TorresPacific Biosciences Research Center, School of Ocean and Earth Science and Technology, University of Hawaii at Manoa, Honolulu, Hawaii, United States.
John D BrockmanMissouri University Research Reactor, University of Missouri-Columbia, Columbia, Missouri, United States.
Suguru KurokawaDepartment of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii, United States.ORCID 0009-0000-6602-3350
Kris L EwellDepartment of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii, United States.
Miyoko T BellingerDepartment of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii, United States.
Pamela TohPacific Biosciences Research Center, School of Ocean and Earth Science and Technology, University of Hawaii at Manoa, Honolulu, Hawaii, United States.
Gabriela Lagatta Pamplona RemediosPacific Biosciences Research Center, School of Ocean and Earth Science and Technology, University of Hawaii at Manoa, Honolulu, Hawaii, United States.
Naghum AlfulaijPacific Biosciences Research Center, School of Ocean and Earth Science and Technology, University of Hawaii at Manoa, Honolulu, Hawaii, United States.ORCID 0000-0002-3997-7973
Sydonie M SwansonPacific Biosciences Research Center, School of Ocean and Earth Science and Technology, University of Hawaii at Manoa, Honolulu, Hawaii, United States.
Ali SeyedaliDepartment of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii, United States.
Ann Marie ZavackiDivision of Endocrinology, Diabetes and Metabolism, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States.
Marla J BerryPacific Biosciences Research Center, School of Ocean and Earth Science and Technology, University of Hawaii at Manoa, Honolulu, Hawaii, United States.ORCID 0000-0002-2428-586X
Lucia A SealePacific Biosciences Research Center, School of Ocean and Earth Science and Technology, University of Hawaii at Manoa, Honolulu, Hawaii, United States.ORCID 0000-0002-0686-7516
Funding
The Role of gp120 on Cardiovascular Disease in People Living with HIVU54MD007601 · NIMHD · UNIVERSITY OF HAWAII AT MANOA · PI Lee Ellen Buenconsejo-Lum, Jerris Robert Hedges · 2017 to 2026
$59.5MUniversity of Hawaii Cancer Center CCSGP30CA071789 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI GERTRAUD MASKARINEC · 1996 to 2026
$56.2MSelenium Metabolism in the Heart: Impact of High Fructose and Low SeleniumP20GM139753 · NIGMS · UNIVERSITY OF HAWAII AT MANOA · PI Marla J Berry · 2022 to 2026
$13.3MMECHANISM OF SELENOPROTEIN SYNTHESIS IN EUKARYOTESR01DK047320 · NIDDK · UNIVERSITY OF HAWAII AT MANOA · PI BERRY, MARLA J · 1994 to 2020
$5.8MTraining in Cardiovascular Research at the University of HawaiiT32HL115505 · NHLBI · UNIVERSITY OF HAWAII AT MANOA · PI Michelle D Tallquist · 2012 to 2026
$3.8MOne Health Research Training Curriculum for Native Hawaiians and Pacific StudentsT34GM141986 · NIGMS · UNIVERSITY OF HAWAII AT MANOA · PI GERSCHENSON, MARIANA, RIVERS, RACHEL · 2021 to 2025
$2.1MSelenium metabolism in cold-induced adaptive thermogenesisR01DK128390 · NIDDK · UNIVERSITY OF HAWAII AT MANOA · PI SEALE, LUCIA ANDREIA · 2021 to 2025
$2.0MInvestigating sex-specific metabolic effects of disrupted selenocysteine lyase and selenocysteine tRNA in Agrp hypothalamic neuronsF32DK124963 · NIDDK · UNIVERSITY OF HAWAII AT MANOA · PI TORRES, DANIEL J. · 2020 to 2022
$206kHawai'i Community Foundation (HCF) MedRes_2023_00002973HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) 2T32HL115505-11HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) F32DK124963HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) R01DK047320HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) R01DK047320-22S1HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) R01DK128390HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) R01DK128390-02S1HHS | NIH | National Institute of General Medical Sciences (NIGMS) P20GM13975HHS | NIH | National Institute of General Medical Sciences (NIGMS) P20GM139753 sub-award 9953HHS | NIH | National Institute of General Medical Sciences (NIGMS) T34GM141986HHS | NIH | National Institute on Minority Health and Health Disparities (NIMHD) U54MD007601 - subproject 5544NCI NIH HHS P30 CA071789NHLBI NIH HHS T32 HL115505NIDDK NIH HHS F32 DK124963NIDDK NIH HHS R01 DK047320NIDDK NIH HHS R01 DK128390NIGMS NIH HHS P20 GM139753NIGMS NIH HHS T34 GM141986NIMHD NIH HHS U54 MD007601
Abstract
The enzyme selenocysteine (Sec) lyase (SCLY) decomposes Sec, releasing selenide for the synthesis of selenoproteins, which contain Sec in their primary structure and participate in strong redox reactions, maintaining redox balance. We previously showed that global disruption of the
Indexed as
Adipocytes, BrownLipid MetabolismLyasesAdipose Tissue, BrownAnimalsEnergy MetabolismGlutathione PeroxidaseIodide PeroxidaseMaleMiceMice, Inbred C57BLMice, KnockoutObesitySeleniumSelenoproteinsGlutathione PeroxidaseIodide PeroxidaseLyasesSeleniumselenocysteine lyaseSelenoproteinsBATobesityselenocysteine lyaseselenoproteinsthermogenesis
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.