Evidence map›Paper›PMID 41452580›Full record

ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2026

Association of left ventricular end-diastolic volume with core temperature and heart rate during very hot and dry heat stress in older adults.

Zachary J McKenna, Satyam Sarma, Whitley C Atkins, Elizabeth A Gideon, Jacob L McNary, Craig G Crandall

Abstract read
In one paragraph

Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zachary J McKennaDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, United States.ORCID 0000-0003-2502-8870
Satyam SarmaDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, United States.ORCID 0000-0002-0628-4919
Whitley C AtkinsDepartment of Health, Exercise and Sports Sciences, University of New Mexico, Albuquerque, New Mexico, United States.ORCID 0000-0003-1610-048X
Elizabeth A GideonDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, United States.ORCID 0009-0002-6877-681X
Jacob L McNaryInstitute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, Dallas, Texas, United States.ORCID 0009-0008-4518-4487
Craig G CrandallDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, United States.ORCID 0000-0001-7792-9713

Funding

Heat waves and the elderly: reducing thermal and cardiovascular consequencesR01AG069005 · NIA · UT SOUTHWESTERN MEDICAL CENTER · PI CRANDALL, CRAIG G · 2021 to 2025
$2.8M
Heat waves and the elderly: reducing thermal and cardiovascular consequencesR56AG069005 · NIA · UT SOUTHWESTERN MEDICAL CENTER · PI CRANDALL, CRAIG G · 2020 to 2020
$717k
Low-energy cooling strategies to reduce the thermal, cardiovascular, and renal consequences of heat waves in the elderly.F32HL168826 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI MCKENNA, ZACHARY JOHN · 2024 to 2025
$149k
American Heart Association (AHA) 23POST1023065American Heart Association (AHA) 24POST1192222American Heart Association-American Stroke Association 23POST1023065HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) F32HL168826HHS | NIH | National Institute on Aging (NIA) R01AG069005NHLBI NIH HHS F32 HL168826NIA NIH HHS R01 AG069005NIA NIH HHS R56 AG069005
6 · The paper itself

Abstract

There is considerable heterogeneity in the thermal and cardiovascular responses to heat stress, even among older adults within a similar age range; hence, age alone may not predict heat-related risks. This variability may be in part explained by differences in cardiorespiratory fitness. We aimed to identify whether left ventricular end-diastolic volume (LVEDV), a characteristic of cardiorespiratory fitness, was associated with core temperatures and heart rate responses in older adults exposed to 3 h of very hot and dry heat stress. We hypothesized that individuals with smaller LVEDV would exhibit higher ending core temperature and heart rates following heat stress. Twenty-two older adults (73 ± 5 yr; 10 females) were exposed to 3 h of very hot and dry ambient heat stress (47°C, 15% relative humidity) with accompanying activities of daily living. We assessed thermal and cardiovascular responses at baseline and end-heating. End core temperature ranged from 37.4°C to 38.9°C, whereas end heart rate ranged from 53 to 113 beats/min. Baseline LVEDV was associated with end-heating core temperature (β = -0.018, SE = 0.004;

Indexed as

Body TemperatureBody Temperature RegulationHeart RateHeat-Shock ResponseHeat Stress DisordersStroke VolumeVentricular Function, LeftAgedAged, 80 and overAge FactorsAgingCardiorespiratory FitnessFemaleHot TemperatureHumansMaleagingcardiovascularthermal

Identifiers

PMID41452580
PMCPMC12841276

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.