Evidence map›Paper›PMID 41452537›Full record

ArticleNeurosurgical review2025

Intrinsic and extrinsic risk factors in tumor-related epilepsy.

Omar Rafi, Alessandro Carretta, Luca Zanuttini, Victor Staartjes, Flavio Vasella, Stefanos Voglis, Michael Weller, Niklaus Krayenbühl, Luca Regli, Carlo Serra and 1 more

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Article in Neurosurgical review, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Omar RafiDepartment of Neurosurgery, Clinical Neuroscience Center, University Hospital Zurich, University of Zurich, Zurich, Switzerland. o.rafi26@gmail.com.
Alessandro CarrettaDepartment of Neurosurgery, Clinical Neuroscience Center, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Luca ZanuttiniDepartment of Neurosurgery, Clinical Neuroscience Center, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Victor StaartjesDepartment of Neurosurgery, Clinical Neuroscience Center, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Flavio VasellaDepartment of Neurosurgery, Clinical Neuroscience Center, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Stefanos VoglisDepartment of Neurosurgery, Clinical Neuroscience Center, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Michael WellerDepartment of Neurology, Clinical Neuroscience Center, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Niklaus KrayenbühlDivision of Pediatric Neurosurgery, University Children's Hospital, Zurich, Switzerland.
Luca RegliDepartment of Neurosurgery, Clinical Neuroscience Center, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Carlo Serra *Department of Neurosurgery, Clinical Neuroscience Center, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Kevin Akeret *Department of Neurosurgery, Clinical Neuroscience Center, University Hospital Zurich, University of Zurich, Zurich, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study consolidated evidence on the association of tumor-intrinsic and investigated the underexplored association of tumor-extrinsic factors with tumor-related epilepsy, aiming to contribute to the overall risk assessment for clinical management in tumor-related epilepsy. MATERIAL &

methodsOver a period of one year (2020), we prospectively collected imaging and clinical data of 373 patients with histopathologically confirmed brain tumors. Assessed tumor-intrinsic factors included histopathology, diameter and anatomical location, with the central lobe comprising the precentral, postcentral and subcentral gyrus and paracentral lobule. Tumor-extrinsic factors comprised sex, age, BMI, smoking, alcohol abuse, and Na

resultsPreoperative seizures occurred in 29.5% (n = 110) of patients, with cortical locations - particularly the central lobe (91.3%, n = 21) - posing the highest seizure incidence among all factors. In univariable analysis, compared to WHO grade 3/4 gliomas, WHO grade 1/2 neuroepithelial tumors exhibited moderately higher, whereas pituitary adenomas/ craniopharyngiomas and schwannomas showed lower incidences of preoperative seizures. In multivariable analysis, the central lobe (OR 58.15), other cortical locations (OR 3.47-3.76), male sex (OR 1.77), low BMI (OR 4.61) and smoking (OR 1.013 per pack-year), revealed significant associations (p = < 0.05).

conclusionCortical location, especially in the central lobe, male sex, low BMI and smoking, are independently associated with tumor-related epilepsy. Our findings support the importance of considering both tumor-intrinsic and tumor-extrinsic factors to develop a holistic seizure-risk assessment and highlight the need for larger, prospective studies to refine clinical management and potentially pharmacological seizure prophylaxis.

Indexed as

Brain NeoplasmsEpilepsyAdolescentAdultAgedFemaleHumansMaleMiddle AgedProspective StudiesRisk FactorsSeizuresYoung AdultAnatomyGliomaMetastasesSeizureTopography

Identifiers

PMID41452537
PMCPMC12743018

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.