SynthesisArchives of orthopaedic and trauma surgery2025
Early vs. late definitive fixation of pelvic ring fractures in resuscitated polytraumatized patients: a systematic review and meta-analysis.
Synthesis in Archives of orthopaedic and trauma surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Efficacy and safety of fast-track surgical management for acute orthopedic fractures: a retrospective cohort analysis.BMC surgery · 2026Article
- 1-Year Follow-Up Result of Early Definitive Management of the Trauma Patient in a Tertiary Health Care Centre.Journal of orthopaedic case reports · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of this systematic review is to compare the short-term clinical outcomes between early (EDF) and late definitive fixation (LDF) in polytraumatized patients with pelvic ring fractures (PRF).
methodIn accordance with PRISMA guidelines, a comprehensive search using Boolean operators was performed in June 2022 from the following databases: Embase, Medline and Cochrane Library. Studies comparing EDF and LDF for PRF in polytrauma patients defined as ISS > 15 were included. All included cohorts performed definitive fixation after haemodynamic stabilisation or adequate response to resuscitation. Random effects meta-analyses of pooled raw data were employed using the Mantel-Haenszel and Inverse -variance methods. The methodological quality of studies was assessed using the Newcastle Ottawa Scale.
resultsOut of 869 studies screened, 10 were included in the meta-analysis with a total of 2918 patients. All included studies were retrospective; no randomized trials were identified. The most common time point used by 7 studies to define EDF was within 24 h of hospital admission and LDF (> 24 h). The most common reasons for LDF were surgeon’s choice, availability of pelvic surgeon and transfer from other hospitals. Our meta-analysis revealed that EDF was associated with a reduced length of hospital stay (WMD=-3.52 days; 95% CI: [-5.43 to -1.62], p < 0.0003) and lower incidence of ARDS (RR = 0.50; 95% CI: [0.26 to 0.96], p = 0.04). No significant association was found in mortality, length of ICU stay, multi-organ failure, sepsis and surgical site infection between EDF and LDF.
conclusionThese findings suggest that early definitive fixation may be a safe and viable option with no increased risk of complications and mortality. However, the adequacy of resuscitation and the estimate of physiologic reserve should be balanced with the risks of operative fixation in all patients. Further prospective validation studies are warranted to test the predictive ability of the various proposed trauma care models and stratify patients for EDF.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.