Trial reportAnesthesiology2026
Individualized Perioperative Blood Pressure and Fluid Therapy in Esophagectomy: A Prospective, Single-blind Randomized Controlled Trial.
Trial report in Anesthesiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- The seduction of the target: individualized hemodynamics and the limits of precision care after esophagectomy.Journal of thoracic disease · 2026Article
- Adherence to home nutritional management in patients following esophagectomy: a qualitative study based on the Health Belief Model.Frontiers in nutrition · 2026Article
Corrections and comments
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEsophagectomy is a key treatment for esophageal cancer but carries a high risk of postoperative complications, some of which are potentially preventable through optimized hemodynamic management. Goal-directed fluid therapy individualizes cardiac output targets but often applies fixed blood pressure thresholds and is discontinued before major postoperative fluid shifts occur. Extending goal-directed fluid therapy into the postoperative period with individualized blood pressure thresholds may address these limitations.
methodsIn this single-center, prospective, blinded, randomized controlled trial, patients undergoing esophagectomy were randomized 1:1 to either extended goal-directed fluid therapy or standard care. In the extended goal-directed fluid therapy group, cardiac output was optimized and mean arterial pressure threshold was the individual patient's nighttime baseline. The protocol continued from tracheal intubation through to 7:00 am the following morning. The primary outcome was total postoperative morbidity, measured by the Comprehensive Complication Index at day 30.
resultsOf 100 patients (49 extended goal-directed fluid therapy group, 51 standard group), extended goal-directed fluid therapy was associated with a higher fluid balance (2,517 ± 1,194 ml vs. 2,001 ± 1,114 ml; mean difference, 516 ml; 95% CI, 57 to 974; P = 0.028), increased norepinephrine use (median, 7,894 μg [interquartile range, 3,946-13,793] vs. 4,611 μg [interquartile range, 2,138 to 7,296]; P < 0.001), and higher mean arterial pressure (mean difference, 3 mmHg; 95% CI, 1 to 5; P = 0.011). At day 30, the mean Comprehensive Complication Index did not differ between groups (39.0 ± 20.0 vs. 39.2 ± 21.0; mean difference, -0.2; 95% CI, -8.6 to 8.1; P = 0.95).
conclusionsDespite achieving protocol-driven treatment differences, extended and individualized goal-directed fluid therapy did not reduce postoperative complications after esophagectomy.
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Identifiers
41452340What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.