ArticleChemistry (Weinheim an der Bergstrasse, Germany)2026
Novel Bioactive Multifunctional Polyphenols: A Chemo-Enzymatic Approach.
Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Novel Bioactive Multifunctional Polyphenols: A Chemo-Enzymatic Approach.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Stilbenes, such as resveratrol, possess numerous biological activities desirable in various industrial sectors (e.g., pharmaceutical, nutraceutical, and cosmetic). However, these activities are counteracted by their low bioavailability. In order to achieve an optimal hydrophylic/lipophilic balance (HLB) and thus maximize bioavailability, alkyl glucoside dimers of resveratrol (i.e., C2 to C12 alkyl oxystilbenin diglucosides (C8-O4' linkage) and δ-Viniferin diglucoside (C3-C8' linkage)) were synthesized from piceid-a β-glucoside of resveratrol-in one or two steps using a silver acetate-mediated oxidative coupling in various alcoholic solvents as the key step. δ-Viniferin diglucoside was functionalized by lauric acid using an enzyme-mediated esterification. HLB values, determined from Log P (the partition coefficient between water and octan-1-ol), were calculated for the nine synthesized compounds, revealing that four exhibited values within the range considered favorable for bioabsorption. Finally, antiradical and antioxidant activities were assessed using DPPH and ORAC tests, respectively, prior to anti-inflammatory testing on dermal human cells. These assays have shown very promising results with some activities overpassing that of resveratrol.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.