Evidence map›Paper›PMID 41452009›Full record

ArticleJournal of the American Chemical Society2026

Deciphering Ibogaine's Matrix Pharmacology: Multiple Transporter Modulation at Serotonin Synapses.

Christopher Hwu, Václav Havel, Xavier Westergaard, Adriana M Mendieta, Inis C Serrano, Jennifer Hwu, Donna Walther, David Lankri, Tim Luca Selinger, Keer He and 13 more

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Molecular Physiology of the Neuronal Synapse.Current issues in molecular biology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Christopher HwuDepartment of Chemistry, Columbia University, New York, New York 10027, United States.
Václav HavelDepartment of Chemistry, Columbia University, New York, New York 10027, United States.
Xavier WestergaardDepartment of Biological Sciences, Columbia University, New York, New York 10027, United States.
Adriana M MendietaDepartment of Chemistry, Columbia University, New York, New York 10027, United States.
Inis C SerranoDepartment of Chemistry, Columbia University, New York, New York 10027, United States.
Jennifer HwuDepartment of Chemistry, Columbia University, New York, New York 10027, United States.
Donna WaltherDesigner Drug Research Unit, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, United States.
David LankriDepartment of Chemistry, Columbia University, New York, New York 10027, United States.
Tim Luca SelingerDepartment of Chemistry, Columbia University, New York, New York 10027, United States.
Keer HeDepartment of Chemistry, Columbia University, New York, New York 10027, United States.
Rose LiuDepartment of Biology, Barnard College, New York, New York 10027, United States.
Tyler P ShernDepartment of Chemistry, Columbia University, New York, New York 10027, United States.
Steven SunDepartment of Chemistry, Columbia University, New York, New York 10027, United States.
Boxuan MaDepartment of Biological Sciences, Columbia University, New York, New York 10027, United States.
Bruno GonzálezDepartment of Chemistry, Columbia University, New York, New York 10027, United States.ORCID 0000-0003-2854-0714
Luisina RodriguezLaboratorio de Síntesis Orgánica, Departamento de Química Orgánica, Facultad de Química, Universidad de la República, Montevideo 11800, Uruguay.
Hannah J GoodmanDepartment of Chemistry, Columbia University, New York, New York 10027, United States.
Hunter WuDepartment of Chemistry, Columbia University, New York, New York 10027, United States.
Mark S SondersDivision of Molecular Therapeutics, New York State Psychiatric Institute, New York, New York 10032, United States.
Michael H BaumannDesigner Drug Research Unit, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, United States.ORCID 0000-0001-7758-1470
Ignacio CarreraLaboratorio de Síntesis Orgánica, Departamento de Química Orgánica, Facultad de Química, Universidad de la República, Montevideo 11800, Uruguay.ORCID 0000-0002-6053-3162
David SulzerDepartment of Psychiatry, Columbia University Irving Medical Center, New York, New York 10032, United States.ORCID 0000-0001-7632-0439
Dalibor SamesDepartment of Chemistry, Columbia University, New York, New York 10027, United States.ORCID 0000-0001-6911-2260

Funding

The Dopamine Synapse and Associative LearningR01DA007418 · NIDA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI David Sulzer · 1999 to 2026
$9.4M
Development of Fluorescent False NeurotransmittersR01MH108186 · NIMH · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI SAMES, DALIBOR, SULZER, DAVID · 2015 to 2024
$5.8M
Chemistry and Pharmacology of Iboga AlkaloidsR01DA050613 · NIDA · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI DALIBOR SAMES · 2020 to 2026
$4.1M
Cryoprobe Upgrade of a 500 MHz NMR SpectrometerS10OD026749 · OD · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI DECATUR, JOHN D · 2019 to 2019
$376k
Intramural NIH HHS ZIADA00052-17NIDA NIH HHS R01 DA007418NIDA NIH HHS R01 DA050613NIH HHS S10 OD026749NIMH NIH HHS R01 MH108186
6 · The paper itself

Abstract

Ibogaine is the main psychoactive alkaloid produced by the iboga tree (

Indexed as

IbogaineSerotoninSynapsesVesicular Monoamine Transport ProteinsAnimalsHumansMiceSerotonin Plasma Membrane Transport ProteinsIbogaineSerotoninSerotonin Plasma Membrane Transport ProteinsVesicular Monoamine Transport Proteins

Identifiers

PMID41452009
PMCPMC13600255

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.