Evidence map›Paper›PMID 41451925›Full record

ArticleClinical and translational science2026

Lexicon for Clonal Hematopoiesis in Liquid Biopsy.

Robert Tell, Ahmet Zehir, Andrew T Anfora, Gargi Basu, Michelle Beidelschies, Carolyn Compton, Stephen Cristiano, James H Godsey, John Hu, Donald J Johann and 12 more

Abstract read
In one paragraph

Article in Clinical and translational science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Liquid biopsy in solid tumours: expert opinion paper of the European society of pathology.Virchows Archiv : an international journal of pathology · 2026
    Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Lexicon for Clonal Hematopoiesis in Liquid Biopsy.Clinical and translational science · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Robert TellTempus AI, Inc., Chicago, Illinois, USA.ORCID 0009-0002-0482-3701
Ahmet ZehirNatera, Austin, Texas, USA.ORCID 0000-0001-5406-4104
Andrew T AnforaLGC Clinical Diagnostics, Milford, Massachusetts, USA.ORCID 0000-0003-3849-1784
Gargi BasuExact Sciences, Madison, Wisconsin, USA.ORCID 0000-0003-0352-5972
Michelle BeidelschiesExact Sciences, Madison, Wisconsin, USA.ORCID 0000-0002-6344-0674
Carolyn ComptonSchool of Life Sciences, Arizona State University, Tempe, Arizona, USA.ORCID 0000-0002-6904-2765
Stephen CristianoDelfi Diagnostics, Baltimore, Maryland, USA.ORCID 0000-0002-7375-2364
James H GodseyFormerly With Quest Diagnostics, Secaucus, New Jersey, USA.ORCID 0000-0002-0206-8354
John HuExact Sciences, Madison, Wisconsin, USA.ORCID 0009-0001-4020-5073
Donald J JohannUniversity of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.ORCID 0009-0002-3173-6910
Marisa JuntillaGuardant Health, Redwood City, California, USA.ORCID 0000-0003-0872-9341
Rina KansalMolecular Oncology and Genetics, Diagnostic Laboratories, Versiti Blood Center of Wisconsin, Milwaukee, Wisconsin, USA.ORCID 0000-0003-4289-3057
Christine LoTempus AI, Inc., Chicago, Illinois, USA.
Dorys Lopez RamosBLOODPAC, Chicago, Illinois, USA.ORCID 0009-0008-1415-3135
Vaidhyanathan MahaganapathyEllison Medical Institute, Los Angeles, California, USA.ORCID 0000-0003-0577-2870
David MerriamLGC Clinical Diagnostics, Milford, Massachusetts, USA.
Christian RolfoInternational Society of Liquid Biopsy, Granada, Spain.ORCID 0000-0002-7860-8417
Hugh RussellAstraZeneca, Wilmington, Delaware, USA.
Usha SinghJohnson & Johnson, New Brunswick, New Jersey, USA.
Daniel StetsonAstraZeneca, Wilmington, Delaware, USA.ORCID 0000-0002-3961-2739
Martin YouExact Sciences, Madison, Wisconsin, USA.ORCID 0009-0006-2729-8582
Lauren C LeimanEllison Medical Institute, Los Angeles, California, USA.ORCID 0009-0002-4374-7246

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Historically, clonal hematopoiesis (CH) has been recognized as a confounder of cell-free DNA (cfDNA) testing. Recent evidence now demonstrates the role of CH as a risk factor in health, generating distinct sources of cfDNA that can be leveraged for liquid biopsy diagnostics. Nonetheless, gaps in standardization challenge the advancement of such diagnostics from development to regulatory approval, through clinical trials, and ultimately, to routine implementation. In 2024, the Blood Profiling Atlas in Cancer (BLOODPAC) Consortium, a collaborative infrastructure for developing standards and best practices for liquid biopsy assays, established the CH/clonal hematopoiesis of indeterminate potential (CHIP) Working Group to address the need for accurate identification and removal of CH from liquid biopsy results. As a first step to support the interpretability of CH/CHIP results, the Working Group developed this lexicon to standardize terms and provide a unified vocabulary related to CH and liquid biopsy, DNA sequencing tests, biomarkers, and clinical use cases, facilitating communication within the field. BLOODPAC's CH/CHIP Working Group believes that terminology agreement across these various stakeholders can improve communication in the field and unify future data collection efforts across studies.

Indexed as

Biomarkers, TumorCell-Free Nucleic AcidsClonal HematopoiesisNeoplasmsTerminology as TopicHumansLiquid BiopsyBiomarkers, TumorCell-Free Nucleic AcidsCHCHIPliquid biopsy

Identifiers

PMID41451925
PMCPMC12741886

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.