Evidence map›Paper›PMID 41451919›Full record

ArticleCurrent protocols2025

Analyzing Large Connectome Graphs With BossDB Network Tools.

Jordan K Matelsky, Hannah Martinez, Daniel Xenes, Michael Robinette, Akshita Panigrahi, Brock Wester

Abstract read
In one paragraph

Article in Current protocols, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Physical contact reveals a hidden layer of cortical architecture.bioRxiv : the preprint server for biology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jordan K MatelskyJohns Hopkins Applied Physics Laboratory, Laurel, Maryland.ORCID https://orcid.org/0000-0002-9470-760X
Hannah MartinezJohns Hopkins Applied Physics Laboratory, Laurel, Maryland.ORCID https://orcid.org/0009-0002-4561-1203
Daniel XenesJohns Hopkins Applied Physics Laboratory, Laurel, Maryland.
Michael RobinetteJohns Hopkins Applied Physics Laboratory, Laurel, Maryland.
Akshita PanigrahiJohns Hopkins Applied Physics Laboratory, Laurel, Maryland.
Brock WesterJohns Hopkins Applied Physics Laboratory, Laurel, Maryland.

Funding

Boss: A cloud-based data archive for electron microscopy and x-ray microtomographyR24MH114785 · NIMH · JOHNS HOPKINS UNIVERSITY · PI BROCK A. WESTER · 2018 to 2026
$6.9M
NIMH NIH HHS R24 MH114785
6 · The paper itself

Abstract

Modern connectomics enables large-scale, comparative network neuroscience across individuals, species, development, and evolution. The field now regularly produces extensive maps of neural connectivity exceeding hundreds of millions of synapses in continuous volumes. When connectomes are deposited in central archives such as BossDB with standardized metadata, researchers can pose previously intractable questions about neuronal networks. Here, we present step-by-step protocols for connectome dataset discovery and access, scalable graph construction and analysis, and reproducible comparative connectomics using BossDB, Motif Studio, DotMotif, Neuroglancer, neuPrint, and Python-based workflows. These protocols target bench neuroscientists and computational biologists and emphasize replicability, cloud-friendly options, and publication-quality visualization. © 2025 Wiley Periodicals LLC. Basic Protocol 1: Discovering connectome datasets and computing summary statistics with BossDB and Motif Studio Basic Protocol 2: Writing queries with DotMotif Basic Protocol 3: Querying known network motifs locally with DotMotif Support Protocol 1: Provisioning ad hoc graph databases for large-scale graph analysis Support Protocol 2: Querying structures and systems in the cloud with neuPrint Basic Protocol 4: Viewing anatomical motif features with BossDB and Neuroglancer.

Indexed as

Computational BiologyConnectomeNeurosciencesAnimalsDatabases, FactualDatasets as TopicData VisualizationHumansNerve NetSoftwareWorkflowBossDBcloud computingcomparative neuroscienceconnectomicsdata visualizationgraph theorynetwork analysis

Identifiers

PMID41451919
PMCPMC13080708

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.