ArticleACS synthetic biology2026
Artificial Multidomain Ribosomally Synthesized and Post-translationally Modified Peptide Enzymes for Farnesylated Peptide Library Generation.
Article in ACS synthetic biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Cyanobactin biosynthetic pathways are used in synthetic biology approaches to create large, peptide-based chemical libraries with drug-like features such as N-C macrocyclization and prenylation. It remains challenging to express enzymes from multiple RiPP pathways to rationally produce the desired products. Here, we designed a simple yet robust method aimed to produce and assess multiple enzymes, fusing biosynthetic genes together in a well-expressed, soluble construct that enables production of macrocyclic peptides and selectively appends C
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