ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025
Structural similarity networks reveal brain vulnerability in dementia.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed.
- Transcriptional signatures of cortical morphometric variability in temporal lobe epilepsy.Epilepsia open · 2026Article
- The genetic architecture of cortical similarity networks.Nature communications · 2026Article
- Structural similarity networks reveal brain vulnerability in dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Generalizable MRI normative modelling to detect age-inappropriate neurodegeneration.Alzheimer's research & therapy · 2025Article
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Abstract
introductionAlzheimer's disease (AD) is characterized by inter-individual heterogeneity in brain degeneration, limiting diagnostic and prognostic precision. We present a novel framework integrating Morphometric Inverse Divergence (MIND) networks with hierarchical Bayesian large-scale population modeling to identify individual-level neuroanatomical deviations.
methodsMIND networks quantify similarity between brain regions using multivariate magnetic resonance imaging (MRI) features. A normative model of regional MIND values trained on UK Biobank (N = 35,133) was applied to the National Alzheimer's Coordinating Center cohort (N = 3,567). We examined brain deviations across clinical stages, apolipoprotein E (APOE) genotypes, mortality risk, and neuropathological burden.
resultsNegative deviations (reduced MIND) stratified disease stages (p < 0.01) and were concentrated in specific functional networks in AD. Greater negative deviations characterized APOE ε4 homozygotes and correlated with post mortem neuropathological severity (p = 0.032). Spatially, deviation patterns were associated with maps of neurotransmitter receptor density. DISCUSSION: This population neuroimaging modeling enables individualized brain mapping with direct utility for diagnosis, prognosis, and understanding of biological mechanisms. HIGHLIGHTS: MIND networks were systematically integrated with normative modeling in AD. Negative deviations stratify clinical stages and correlate with neuropathology. Negative deviation count distinguishes APOE genotypes, highest in ε4 homozygotes. Deviations align with neurotransmitter maps. Individual brain maps enable precision medicine approaches in dementia.
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