ArticleJournal of diabetes investigation2026
Long-term remission of type B insulin resistance syndrome with immunotherapy: A case report.
Article in Journal of diabetes investigation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
We report long-term remission in a patient with type B insulin resistance achieved with a combination of immunotherapies. A 55-year-old Japanese man presented with nocturnal hypoglycemia and cytopenia. He also had postprandial hyperglycemia due to severe insulin resistance, which was difficult to manage using high-dose insulin and recombinant human insulin-like growth factor-1. Serological testing showed type B insulin resistance syndrome associated with systemic lupus erythematosus. Glucocorticoids and mycophenolate/azathioprine combination therapy were introduced, resulting in a prompt improvement in glycemic control. The patient has remained in clinical and serological remission for 8 years. Over the past year, he achieved euglycemia with azathioprine monotherapy, without the need for insulin or oral antiglycemic agents.
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