Evidence map›Paper›PMID 41451817›Full record

ArticleHead & neck2026

Efficacy of Multimodal Work-Up of Head and Neck Squamous Cell Carcinoma Lymph Node Metastasis of Unknown Primary.

Robin W Jansen, Roland M Martens, Obaida Abdulrahman, Laura Peferoen, C René Leemans, Gerben J C Zwezerijnen, Jan-Jaap Hendrickx, Pim de Graaf

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Head & neck, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Robin W JansenDepartment of Otolaryngology-Head and Neck Surgery, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.ORCID 0000-0003-0347-1919
Roland M MartensDepartment of Radiology and Nuclear Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
Obaida AbdulrahmanDepartment of Otolaryngology-Head and Neck Surgery, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
Laura PeferoenCancer Center Amsterdam, Imaging and Biomarkers, Amsterdam, the Netherlands.
C René LeemansDepartment of Otolaryngology-Head and Neck Surgery, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
Gerben J C ZwezerijnenDepartment of Radiology and Nuclear Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
Jan-Jaap HendrickxDepartment of Otolaryngology-Head and Neck Surgery, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
Pim de GraafDepartment of Radiology and Nuclear Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHead and neck squamous cell carcinoma (HNSCC) often presents with cervical lymph node metastasis, with 1%-4% of cases presenting as cancer of unknown primary (CUP). CUP poses diagnostic and therapeutic challenges and is linked to poorer survival outcomes. Its incidence is expected to rise with the increasing prevalence of HPV-positive HNSCC. This study evaluated the use of MRI,

methodsThis single-center retrospective study included 79 patients with cytologically confirmed CUP (years 2019-2024). HPV-positive (n = 51) and HPV-negative (n = 28) cases were evaluated separately. Primary tumor detection rates for MRI,

resultsIn HPV-positive cases MRI and

conclusionMRI and

Indexed as

Head and Neck NeoplasmsLymphatic MetastasisMultimodal ImagingNeoplasms, Unknown PrimarySquamous Cell Carcinoma of Head and NeckAdultAgedAged, 80 and overFemaleFluorodeoxyglucose F18HumansMagnetic Resonance ImagingMaleMiddle AgedPositron-Emission TomographyRetrospective StudiesFluorodeoxyglucose F1818F‐FDG PETEUAhead and neck squamous cell carcinomahead & neck carcinoma unknown primaryMRItrans‐oral surgical techniques

Identifiers

PMID41451817
PMCPMC13155188

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.