ArticleJournal of agricultural and food chemistry2026
Therapeutic Effects of Camel Milk Exosomes and Their miR-148a-3p Cargo on DSS-Induced Colitis: Modulating Gut Inflammation through the SIRT1/NF-κB Pathway and Microbiota Alterations.
Article in Journal of agricultural and food chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Article
- Camel Milk and Its Bioactive Components in Diseases Associated with Aging: A Narrative Review.Nutrients · 2026Review
- Camel Milk Extracellular Vesicles as Functional Foods and Nutraceuticals: Bridging Dairy Science and Chronic Disease Prevention.International journal of molecular sciences · 2026Review
- Red Ginseng Ethanolic Extract Alleviates DSS-Induced Colitis in Mice by Suppressing Inflammatory Mediator Production.International journal of molecular sciences · 2026Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Camel milk contains abundant bioactive compounds, but the therapeutic potential of its exosomes as natural delivery systems for gut health remains unclear. This study investigated the therapeutic effects and underlying mechanisms of camel milk exosomes (CME) and their enriched miRNA cargo, miR-148a-3p, on dextran sodium sulfate (DSS)-induced ulcerative colitis (UC) in mice. Both CME and miR-148a-3p significantly alleviated colitis symptoms, including weight loss, colon shortening, and disease activity scores. These effects were achieved by suppressing pro-inflammatory cytokines and restoring intestinal barrier integrity through Zonula Occludens-1 (ZO-1) upregulation. Moreover, the treatments promoted M2 macrophage polarization, inhibited NF-κB signaling via silent information regulator T1 (SIRT1) upregulation and increased microbial diversity with the enrichment of beneficial taxa. Notably, the therapeutic effects of miR-148a-3p were comparable to those of CME, underscoring its role as a key functional component. These findings highlight CME as promising natural nanotherapeutics for UC, offering a novel, multitargeted strategy for managing intestinal inflammation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.