Evidence map›Paper›PMID 41451557›Full record

Trial reportJournal of psychopharmacology (Oxford, England)2026

Anti-saccade error rates are associated with somatic depressive symptoms in cocaine use disorder.

Constanza de Dios, Heather E Webber, Margaret C Wardle, Jin H Yoon, Michelle A Patriquin, Jessica N Vincent, Joy M Schmitz, Scott D Lane

Registry-linked trialAbstract readClinical Trial, Phase IIRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of psychopharmacology (Oxford, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02896712 (Developing Adaptive Interventions for Cocaine Cessation and Relapse Prevention), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02896712 phase2completednot on this map

Developing Adaptive Interventions for Cocaine Cessation and Relapse Prevention ("Adaptive Trial")

TypeinterventionalSponsorThe University of Texas Health Science Center, HoustonRan2016 to 2021Enrolled118ConditionsCocaine-Related DisordersArmsAcceptance and Commitment Therapy (ACT), Drug Counseling (DC), Contingency Management (CM), Placebo, Modafinil
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Constanza de DiosFaillace Department of Psychiatry and Behavioral Sciences, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID 0000-0003-0230-5222
Heather E WebberFaillace Department of Psychiatry and Behavioral Sciences, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
Margaret C WardleDepartment of Psychology, University of Illinois at Chicago, Chicago, IL, USA.
Jin H YoonFaillace Department of Psychiatry and Behavioral Sciences, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
Michelle A PatriquinFaillace Department of Psychiatry and Behavioral Sciences, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID 0000-0002-1910-6724
Jessica N VincentFaillace Department of Psychiatry and Behavioral Sciences, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
Joy M SchmitzFaillace Department of Psychiatry and Behavioral Sciences, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
Scott D LaneFaillace Department of Psychiatry and Behavioral Sciences, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundInhibitory control deficits are associated with cocaine use disorder (CUD) development and maintenance. Additionally, drug use and inhibitory control can be negatively affected by depressive symptoms, including somatic factors like sleep disturbance and fatigue.

aimThe current study assessed the relationship between inhibitory control and depressive symptoms among individuals initiating CUD treatment. We examined associations among anti-saccade response inhibition performance, total scores on the Beck Depression Inventory-II (BDI-II), and individual BDI-II items.

methods

resultsAnti-saccade error rates were higher on cocaine relative to neutral trials (

conclusionsAttentional bias was drug-specific, and overall error rates were strongly related to somatic factors underlying depression in CUD. The association between inhibitory control and depression in CUD may be driven by physiological symptomatology, including sleep impairment and fatigue. CLINICALTRIALS: gov:NCT02896712.

Indexed as

Cocaine-Related DisordersDepressionInhibition, PsychologicalSaccadesAdultCocaineFemaleHumansMaleMiddle AgedPsychiatric Status Rating ScalesSleep Wake DisordersCocaineanti-saccadecocaine use disorderdepressioninhibitory controlsleep

Identifiers

PMID41451557
PMCPMC13222382

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.