Evidence map›Paper›PMID 41451513›Full record

ArticleAngewandte Chemie (International ed. in English)2026

Nonheme Fe Enzyme-Catalyzed Enantiodivergent Nitrogen Migration: Directed Evolution and Computational Study of Isopenicillin N Synthases for Biocatalytic Synthesis of Arylglycines.

Ken Lin, Liu-Peng Zhao, Shengchun Wang, Huichong Liu, Yu Zhang, Binh Khanh Mai, Peng Liu, Yang Yang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ken Lin *Department of Chemistry and Biochemistry, University of California Santa Barbara, Santa Barbara, California, 93106, USA.ORCID 0009-0007-5650-4303
Liu-Peng Zhao *Department of Chemistry and Biochemistry, University of California Santa Barbara, Santa Barbara, California, 93106, USA.
Shengchun Wang *Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania, 15260, USA.
Huichong LiuDepartment of Chemistry and Biochemistry, University of California Santa Barbara, Santa Barbara, California, 93106, USA.
Yu ZhangDepartment of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania, 15260, USA.
Binh Khanh MaiDepartment of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania, 15260, USA.
Peng LiuDepartment of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania, 15260, USA.ORCID 0000-0002-8188-632X
Yang YangDepartment of Chemistry and Biochemistry, University of California Santa Barbara, Santa Barbara, California, 93106, USA.ORCID 0000-0002-4956-2034

Funding

An Evolvable Metalloenzyme Platform for Stereoselective Radical BiocatalysisR35GM147387 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI Yang Yang · 2022 to 2026
$2.0M
Alfred P. Sloan Research Fellow FG-2024-22244Camille Dreyfus Teacher-Scholar TC-25-084David & Lucile Packard Fellow 2023-76169Howard Hughes Medical InstituteNational Science Foundation CHE-2400087National Science Foundation OAC-2117681National Science Foundation OAC-2138259NIGMS NIH HHS R35 GM147387NIH HHS R35GM147387
6 · The paper itself

Abstract

We describe the reprogramming and directed evolution of nonheme Fe enzyme isopenicillin N synthase (IPNS) as an efficient biocatalyst for 1,3-nitrogen migration reactions via an unnatural mechanism. Directed evolution of isopenicillin N synthase from Emericella nidulans furnished a quadruple mutant (EniIPNS V185L I187V S102I R279H, IPNS

Indexed as

NitrogenNonheme Iron ProteinsOxidoreductasesAspergillus nidulansBiocatalysisDirected Molecular EvolutionStereoisomerismisopenicillin N synthetaseNitrogenNonheme Iron ProteinsOxidoreductasesAmino acidsAsymmetric synthesisBiocatalysisNonheme Fe enzyme

Identifiers

PMID41451513
PMCPMC12834331

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.