ArticleAmerican journal of men's health
Exploration of the Prognostic Value of PANoptosis-Related Genes in Bladder Cancer.
Article in American journal of men's health. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study systematically investigates the prognostic value and clinical significance of PANoptosis-related genes in bladder cancer (BC). By integrating the TCGA and GEO databases, two PANoptosis molecular subtypes with significant survival differences were identified, with the C2 subtype demonstrating a more favorable prognosis. A prognostic model comprising nine key genes was constructed, demonstrating robust risk stratification capabilities in both training and validation sets. Further analysis revealed that high-risk patients exhibited distinct immunosuppressive microenvironment characteristics, including enrichment of Treg cells and M2 macrophages. Single-cell sequencing analysis elucidated the cell-type-specific expression patterns of these genes within the tumor microenvironment. Experimental validation confirmed the significant overexpression of KCNJ15, FASN, and ADAMTS12 in BC tissues. The prognostic model established in this study provides a novel tool for risk stratification of BC patients while simultaneously establishing the foundation for in-depth exploration of PANoptosis mechanisms in BC.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.