Evidence map›Paper›PMID 41451419›Full record

ArticleFrontiers in neurology2025

Multidisciplinary cognitive performance optimization for mission-critical decision makers: delivering "the whole pizza".

David L Brody

Abstract read
In one paragraph

Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

David L BrodyDepartment of Neurology, Uniformed Services University of the Health Sciences (USUHS) and Walter Reed National Military Medical Center, Bethesda, MD, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite the promise of artificial intelligence, there remains no substitute for human analytical acumen and decision-making. Human cognitive performance is not fixed; it can often be substantially improved through specific interventions. The field of cognitive performance optimization is multidisciplinary, often involving contributions from physicians, psychologists, athletic trainers, therapists, executive coaches, and many other professionals. Key domains include lifestyle factors, treatment of potentially cognitively impairing disorders, careful use of stimulants, and additional personalized interventions. Modifiable lifestyle factors such as sleep, physical exercise, toxic substances, stress management, and diet play a crucial role. Treatable cognitively impairing disorders include sleep apnea, restless leg syndrome, major depressive disorder, persistent depressive disorder, seasonal affective disorder, anxiety disorders, post-traumatic stress disorder (PTSD), migraine with or without neurological aura, vitamin B12 deficiency, hypothyroidism, and obesity. Stimulants, including both prescription stimulants like methylphenidate and non-prescription stimulants like caffeine, can improve fatigue, sustained attention and processing speed with manageable risks when used carefully. Personalized interventions include correction of vision and hearing deficits, cognitive rehabilitation under professional therapist guidance, computer-based cognitive skills training, cognitive performance coaching, and non-invasive brain stimulation. Taken together, addressing these domains in a multidisciplinary fashion can result in meaningful benefits in terms of cognitive performance. However, cognitive performance optimization requires substantial time and effort on the part of the providers and participants as there are rarely any "easy fixes." Importantly, cognitive performance optimization is an evolving science with great promise for future advanced interventions.

Indexed as

caffeinecognitive performancelifestylesleepstimulants

Identifiers

PMID41451419
PMCPMC12728740

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.