ArticleFrontiers in neurology2025
Ethnic disparities in patients with early-onset Alzheimer's disease (EOAD).
Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Ethnic disparities in Early-onset Alzheimer's Disease (EOAD) have not been fully characterized. Methods: We retrospectively identified 81 EOAD patients February 2017-February 2022. Results: 53 (65.4%) identified as White and 28 (34.6%) identified as Black. Age at diagnosis (years) was (57.3 ± 5.24) in Black patients compared to (56.3 ± 4.96) in White patients. Time to diagnosis (years) was longer in Black patients (3.39 ± 1.85) compared with White patients (2.64 ± 1.75). Black patients had lower MOCA scores (12.17 ± 6.9) compared with White patients (14.9 ± 5.8). An amnestic profile was more common in Black patients (19 or 67.9%) than non-amnestic presentations (9 or 32.1%). Non-amnestic presentations were more common in White patients, with 9 (17%) patients with PCA, 8 (15%) with fAD and 8 (15%) with l-PPA. Discussion: In our cohort, Black patients with EOAD are on average older, more advanced and experienced longer delays in diagnosis than their White counterparts.
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