ReviewJournal of diabetes and metabolic disorders2026
Bibliometric analysis of global research trends on the relationship between alzheimer's disease and type 2 diabetes mellitus.
Review in Journal of diabetes and metabolic disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Background: Type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD) are highly prevalent chronic disorders with overlapping pathophysiological features. Increasing evidence suggests a bidirectional association, supported by shared mechanisms such as insulin resistance, neuroinflammation, and amyloid pathology giving rise to the concept of "type 3 diabetes." To map the global scientific output on the T2DM, AD relationship through a comprehensive bibliometric analysis, identifying publication trends, key contributors, and thematic developments. Methods: A search was conducted in the Web of Science database on February 16, 2025, without time or language restrictions. Studies related to the association between T2DM and AD were retrieved and analyzed using VOSviewer and the Bibliometrix package in R. Metrics included publication volume, citation count, authorship, institutional affiliations, journal impact, and keyword co-occurrence. Results: A total of 2,943 articles were identified, with a marked increase in output after 2011. The most cited article, by Craft et al., proposed a mechanistic link between insulin resistance and AD. The United States and China led in publication volume. Key institutions included Huazhong University of Science and Technology and Columbia University. Prominent authors included Hoelscher C and Liu Y. Keyword analysis revealed strong focus on "insulin resistance," "oxidative stress," and "neuroinflammation." Emerging trends included interest in GLP-1 receptor agonists, metformin, and biomarker-guided strategies. Conclusion: Research linking T2DM and AD has expanded substantially, reflecting growing recognition of shared mechanisms. Despite progress, gaps remain in biomarker integration and precision strategies. Future studies should emphasize longitudinal designs, mechanistic targets, and collaborative translational approaches. Supplementary Information: The online version contains supplementary material available at 10.1007/s40200-025-01812-4.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.