ArticleRadiology case reports2026
IgG4-related disease masquerading as malignancy in the abdomen: A diagnostic challenge.
Article in Radiology case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
IgG4-related disease (IgG4-RD) is a fibro-inflammatory autoimmune disorder with an incompletely understood pathophysiology. This condition can affect a wide range of organs, and its hallmark features include tissue damage caused by an inflammatory, mass-forming process, often accompanied by significant fibrosis, venulitis, and a dense lymphoplasmacytic infiltrate rich in IgG4-positive plasma cells. In this report, we describe a rare and atypical case of IgG4-RD in a male in his late twenties who presented with abdominal pain and a palpable bulge. Imaging studies, including abdominal CT, revealed a terminal ileal mass with associated lymphadenopathy, initially raising strong clinical suspicion for a small bowel malignancy. However, further evaluation through colonoscopy and biopsy ultimately confirmed the diagnosis of IgG4-RD. This case underscores the diagnostic complexity of IgG4-RD, especially when it mimics malignancy, and highlights the importance of thorough investigation to ensure accurate diagnosis and appropriate management.
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