Evidence map›Paper›PMID 41451244›Full record

ArticleEuropean heart journal open2025

Multimorbidity and risk of atrial fibrillation in the Lifelines cohort.

Colinda van Deutekom, Liann I Weil, Melissa E Middeldorp, Michelle Samuel, Bastiaan Geelhoed, Marieke J H Velt, Victor W Zwartkruis, Denise J C Hanssen, Barbara C Van Munster, Richard C Oude Voshaar and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European heart journal open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Multimorbidity increases risk of atrial fibrillation recurrence after cryoballoon ablation.International journal of cardiology. Heart & vasculature · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Colinda van DeutekomDepartment of Cardiology, University of Groningen, University Medical Centre Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands.ORCID https://orcid.org/0000-0001-5116-7378
Liann I WeilDepartment of Internal Medicine, University Centre for Geriatric Medicine, University Medical Centre Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands.
Melissa E MiddeldorpDepartment of Cardiology, University of Groningen, University Medical Centre Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands.
Michelle SamuelDepartment of Cardiology, University of Groningen, University Medical Centre Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands.ORCID https://orcid.org/0000-0002-9674-6565
Bastiaan GeelhoedDepartment of Cardiology, University of Groningen, University Medical Centre Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands.
Marieke J H VeltDepartment of Cardiology, University of Groningen, University Medical Centre Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands.ORCID https://orcid.org/0000-0002-2492-844X
Victor W ZwartkruisDepartment of Cardiology, University of Groningen, University Medical Centre Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands.
Denise J C HanssenDepartment of Psychiatry, University of Groningen, University Medical Centre Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands.
Barbara C Van MunsterDepartment of Internal Medicine, University Centre for Geriatric Medicine, University Medical Centre Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands.
Richard C Oude VoshaarDepartment of Psychiatry, University of Groningen, University Medical Centre Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands.
Isabelle C Van GelderDepartment of Cardiology, University of Groningen, University Medical Centre Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands.
Michiel RienstraDepartment of Cardiology, University of Groningen, University Medical Centre Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands.ORCID https://orcid.org/0000-0002-2581-070X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aims: Associations of individual comorbidities with incident atrial fibrillation (AF) are well-studied. However, the impact of multimorbidity and potentially clustering of comorbidities on incident AF remains unclear. This study investigated the number and clustering of (non-)cardiovascular comorbidities with incident AF. Methods and results: We studied 25 (non-)cardiovascular comorbidities in 76 648 participants from the Lifelines cohort. Logistic regression was used to study the association between the number of comorbidities and incident AF. Latent class analysis was used to identify comorbidity clusters. Mean age was 46.4 ± 2.6 years and 59.3% were women. In this population, 56 034 (73.1%) participants had ≥2 comorbidities, 42 575 (55.5%) ≥ 2 cardiovascular comorbidities, and 14 612 (19.1%) ≥ 2 non-cardiovascular comorbidities. After a mean follow-up of 3.70 ± 0.95 years, 188 (0.2%) participants developed incident AF. After adjusting for age and sex, the total number of comorbidities (OR 1.10 [1.01-1.19], Conclusion: There was a dose-dependent relationship between the number of total comorbidities and cardiovascular comorbidities and risk of incident AF, but not for non-cardiovascular comorbidities. We identified 12 comorbidity clusters with different risks of incident AF; however, these clusters were determined by the number of comorbidities rather than specific combinations.

Indexed as

Atrial fibrillationClusteringComorbidityMultimorbidityRisk factors

Identifiers

PMID41451244
PMCPMC12728500

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.