ReviewFrontiers in immunology2025
The immunoregulatory role of integrins in pulmonary diseases.
Review in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Immunohistochemical Evaluation of Integrin β6 Expression in Triple-Negative Breast Cancer as a Predictive Biomarker for Therapeutic and Diagnostic Radionuclides.Biomolecules · 2026Article
- Immunohistochemical Expression of Integrin αBiomolecules · 2026Article
- Article
- Hemodynamics and matrix stiffness shape the pathogenicity of SPP1Frontiers in immunology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Integrins are a family of transmembrane adhesion receptors composed of α and β subunits that connect cells to the extracellular matrix and transmit biochemical and mechanical signals. They play a critical role in immune cell migration, maintenance of the alveolar-capillary barrier, and tissue repair. Pulmonary diseases often exhibit pathological features of immune imbalance, barrier disruption, and abnormal remodeling. Integrins, situated at the intersection of "cell-matrix-mechanical" signaling, exert decisive influence on disease progression by regulating mechanisms such as neutrophil and monocyte transendothelial migration, TGF-β activation, and the immune microenvironment. This review comprehensively summarizes the structural basis and bidirectional signaling mechanisms of integrins, along with their regulatory roles in the functions of pulmonary immune cells such as T cells, macrophages, and neutrophils. It emphasizes the pathological mechanisms of integrins in diseases including ARDS, pulmonary fibrosis, COPD, asthma, and lung cancer (particularly the dual role of the integrin-TGF-β axis in inflammation and fibrosis) It introduces current and emerging targeted therapeutic strategies, including α
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.