Evidence map›Paper›PMID 41451220›Full record

ReviewFrontiers in immunology2025

Multi-omics approach to dissect the significance of lipid metabolism in helper T cell subset.

Toshio Kanno, Keiko Nakano, Yukie Iwao, Yusuke Endo

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Toshio KannoDepartment of Frontier Research and Development, Laboratory of Medical Omics Research, Kazusa DNA Research Institute, Chiba, Japan.
Keiko NakanoDepartment of Frontier Research and Development, Laboratory of Medical Omics Research, Kazusa DNA Research Institute, Chiba, Japan.
Yukie IwaoDepartment of Frontier Research and Development, Laboratory of Medical Omics Research, Kazusa DNA Research Institute, Chiba, Japan.
Yusuke EndoDepartment of Frontier Research and Development, Laboratory of Medical Omics Research, Kazusa DNA Research Institute, Chiba, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The immunometabolism has fundamentally reshaped our understanding of T cell biology. Recent advances have demonstrated that metabolic reprogramming is not merely a consequence of T cell activation but a central driver of lineage specification and effector function. For example, quiescent naïve T cells primarily rely on mitochondrial oxidative phosphorylation (OXPHOS) and fatty acid oxidation (FAO) to meet baseline energy needs, whereas activation triggers a metabolic shift toward anabolic pathways dominated by aerobic glycolysis and

Indexed as

Lipid MetabolismMetabolomicsT-Lymphocytes, Helper-InducerT-Lymphocyte SubsetsAnimalsCell DifferentiationFatty AcidsHumansLymphocyte ActivationMultiomicsOxidative PhosphorylationFatty AcidsAcc1acetyl-CoA carboxylase 1lipid metabolismmemory T cellmulti-omicsT cellTh17 and Treg cells

Identifiers

PMID41451220
PMCPMC12727632

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.