ReviewFrontiers in immunology2025
Research progress on the application of nanobodies in immunity and infectious skin diseases.
Review in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Neuropathic Pain Management Using Novel Biologics in Moderate-to-Severe Hidradenitis Suppurativa.Current pain and headache reports · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In response to the limitations of traditional therapies for immune and infectious skin diseases in terms of tissue penetration, cost, and drug resistance, nanobodies derived from camelids and containing only a single heavy chain variable domain have shown significant advantages: their small molecular weight ensures excellent skin penetration ability, the extended CDR3 domain enables precise targeting of hidden epitopes, and they have excellent stability (tolerance to extreme pH, temperature, protease) and low-cost production potential. In the treatment of immune skin diseases, nanobodies effectively synergistically block key inflammatory pathways through multivalent/multispecific design, demonstrating deep therapeutic effects beyond some traditional therapies in areas such as psoriasis, atopic dermatitis, and hidradenitis suppurativa. In the field of infectious skin diseases, it effectively blocks the process of pathogen infection by efficiently neutralizing key virulence factors (such as invasion proteins, adhesion factors, toxins) of viruses, bacteria, fungi, and parasites, and has the potential to serve as a highly specific diagnostic tool. Future research and development will focus on multi-target optimization, artificial intelligence assisted design, new transdermal/long-acting delivery systems, and precision medicine strategies, promoting nanobodies as an efficient and precise solution to revolutionize the treatment of skin diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.