Evidence map›Paper›PMID 41451177›Full record

ReviewAnnals of surgery open : perspectives of surgical history, education, and clinical approaches2025

A Developmental Roadmap Toward Abdominal Adhesions Prevention Technologies.

Reid R Christensen, Kyla E Wright, James K Ives, Caroline E Minnick, Queena Chen, Mark D Girgis, Cliff Ko, Melinda Maggard Gibbons, Tara A Russell, Tess C Huy and 17 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Annals of surgery open : perspectives of surgical history, education, and clinical approaches, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Cellular and molecular regulation of fibrotic postoperative abdominal adhesions.American journal of physiology. Cell physiology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Reid R ChristensenFrom the Department of Surgery, Wake Forest University School of Medicine, Winston-Salem, NC.
Kyla E WrightDepartment of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA.
James K IvesFrom the Department of Surgery, Wake Forest University School of Medicine, Winston-Salem, NC.
Caroline E MinnickFrom the Department of Surgery, Wake Forest University School of Medicine, Winston-Salem, NC.
Queena ChenFrom the Department of Surgery, Wake Forest University School of Medicine, Winston-Salem, NC.
Mark D GirgisDepartment of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA.
Cliff KoDepartment of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA.
Melinda Maggard GibbonsDepartment of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA.
Tara A RussellDepartment of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA.
Tess C HuyDepartment of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA.
Aron BerczMemorial Sloan Kettering Cancer Center, New York, NY.
J Joshua SmithMemorial Sloan Kettering Cancer Center, New York, NY.
Angela BaileyAmerican College of Surgeons, Chicago, IL.
Richard P G Ten BroekRadbound University Medical Center, Nijmegen, Netherlands.
Rudy Leon de WildeUniversity Hospital for Gynecology, Carl von Ossietzky University, Oldenburg, Germany.
Joel ZindelInstitute of Molecular Health Sciences, ETH Zurich, Zurich, Switzerland.
Jessica C CardenasDepartment of Surgery, University of Colorado, Denver, CO.
Steven MutsaersUniversity of Western Australia, Pharmacology and Toxicology, School of Biomedical Sciences and Institute for Respiratory Health, Nedlands, Western Australia.
David WisemanSynechion Inc, Dallas, TX.
Emily A MeanyDepartment of Bioengineering, Stanford University, Stanford, CA.
Eric A AppelDepartment of Bioengineering, Stanford University, Stanford, CA.
Deshka S FosterMemorial Sloan Kettering Cancer Center, New York, NY.
Daniel J DelittoDepartment of Surgery, Stanford University, Stanford, CA.
Michael T LongakerDepartment of Surgery, Stanford University, Stanford, CA.
Yuval RinkevichChinese Institutes for Medical Research, Institute of Regenerative Biology and Medicine, Beijing, China.
Steven R BauerWake Forest Institute for Regenerative Medicine, Winston-Salem, NC.
Samuel P CarmichaelFrom the Department of Surgery, Wake Forest University School of Medicine, Winston-Salem, NC.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Abdominal adhesions are a globally disruptive problem to patients and healthcare systems, with limited preventative strategies. Multiple discovery prophylactics have been evaluated previously for adhesions prevention with inadequate transfer to patient care. Clinical translation is fundamentally restricted by the ability of a discovery prophylactic to simultaneously navigate 3 key components of adhesions formation throughout the entire abdomen: the innate immune system, the coagulation system, and the local peritoneal cell populations. Furthermore, challenging handling characteristics and product restrictions have decreased the utilization of clinically available prophylactics by surgeons. The success of future adhesions prevention strategies must also be anchored in clinically valid animal modeling with attention towards future regulatory approval. The purpose of the present roadmap article is to provide a state-of-the-art review of adhesions pathophysiology, hydrogel development, animal modeling, and regulatory science, from which a framework for future developmental strategies may be outlined.

Identifiers

PMID41451177
PMCPMC12727408

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.