Observational studyVascular health and risk management2025
Assessing Established Diagnostic Markers of HFpEF in Older Patients Presenting with Acute Dyspnoea in the Emergency Department.
Observational study in Vascular health and risk management, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Heart failure with preserved ejection fraction (HFpEF) is common yet diagnostically challenging in older adults presenting with acute dyspnoea to the emergency department (ED). This study evaluated the diagnostic performance of established markers used in HFpEF assessment, including echocardiographic indices, NT-proBNP, and the H Methods: Between September 2024 and May 2025, we conducted a prospective observational study of patients aged ≥60 years presenting to the ED of a tertiary hospital in Vietnam with acute dyspnoea. HFpEF was identified using the 2021 European Society of Cardiology (ESC) guidelines, which served as the gold-standard diagnostic framework. Baseline characteristics were compared between HFpEF and non-HFpEF groups, and the diagnostic performance of candidate markers was assessed using receiver operating characteristic curve analysis. Results: Among 280 enrolled patients, 118 (42.1%) were newly diagnosed with HFpEF. Sociodemographic, geriatric, clinical, and comorbidity characteristics were comparable between groups. Patients with HFpEF had significantly higher NT-proBNP levels (median 2205 pg/mL vs 150 pg/mL, p<0.001), left ventricular mass index (LVMI) (118.0 ± 12.1 g/m Conclusion: In older adults presenting with acute dyspnoea, NT-proBNP, LVMI, and the H
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