Evidence map›Paper›PMID 41451131›Full record

ArticleFrontiers in physiology2025

Challenges in diagnosing and treating chronic exertional compartment syndrome: perspective from a student nurse with lower extremity pain.

Madelyne Marbel, Robert Knoerl

Abstract read
In one paragraph

Article in Frontiers in physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Madelyne MarbelDepartment of Health Behavior and Clinical Sciences, University of Michigan School of Nursing, Ann Arbor, MI, United States.
Robert KnoerlDepartment of Health Behavior and Clinical Sciences, University of Michigan School of Nursing, Ann Arbor, MI, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic Exertional Compartment Syndrome (CECS) is an uncommon yet debilitating condition that causes activity-induced pain due to increased pressure within muscle compartments. While typically diagnosed through dynamic intercompartmental pressure testing, CECS presents significant diagnostic challenges due to overlapping symptoms with other musculoskeletal conditions. This first-person narrative describes a 23-month journey through inconclusive imaging, multiple rounds of physical therapy, and pressure testing that met, but was ultimately dismissed despite established CECS diagnostic criteria. The case underscores the mismatch that can occur between objective findings and clinical interpretation, particularly when symptoms affect atypical compartments. With surgery ruled out and conservative treatments offering minimal relief, the experience reveals critical gaps in diagnostic consistency, clinician-patient communication, and care pathways for individuals whose symptoms reside in a diagnostic gray zone. This narrative calls for more nuanced application of diagnostic tools, greater attention to patient-reported symptoms, and improved support systems for those navigating prolonged diagnostic uncertainty.

Indexed as

chronic exertional compartment syndromechronic painfasciotomyintramuscular pressure monitoringmusculoskeletal pain

Identifiers

PMID41451131
PMCPMC12727590

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.