ReviewFrontiers in medicine2025
Evaluation of tonsillectomy in the treatment of SAPHO syndrome: past evidence and future directions.
Review in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Can SAPHO syndrome be combined with sinus swelling?Rheumatology advances in practice · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is a rare aseptic inflammatory clinical syndrome characterized by widespread skin lesions and bone-joint lesions. The underlying mechanisms remain unclear, making it difficult to treat. Currently, drug-based symptomatic treatment is the main approach, but symptoms often recur or worsen when medications are reduced or discontinued. Recently, there have been increasing reports of the significant therapeutic effects of tonsillectomy in treating SAPHO syndrome. This paper reviews the past evidence on the use of tonsillectomy for SAPHO syndrome by searching PubMed, Google Scholar, Web of Science, Embase, Scopus, CNKI, and Wanfang databases using the keywords "SAPHO syndrome and tonsillectomy." It also discusses the potential mechanisms of tonsillectomy in treating SAPHO syndrome, aiming to provide new treatment methods for SAPHO syndrome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.