Evidence map›Paper›PMID 41451087›Full record

ArticleFrontiers in medicine2025

Development of serum glycosylated exosomal microRNAs as biomarkers for early diagnosis of lung adenocarcinoma.

Zhixin Huang, Jing Chen, Qi Gao, Kun Hao, Chundong Yu, Yi Huang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zhixin Huang *Department of Clinical Laboratory, Fujian Children's Hospital (Fujian Branch of Shanghai Children's Medical Center), Fuzhou, China.
Jing Chen *Department of Clinical Laboratory, Fuzhou First General Hospital Affiliated with Fujian Medical University, Fuzhou, China.
Qi GaoResearch and Development Center, Beijing Youngen Technology Co. Ltd., Beijing, China.
Kun HaoResearch and Development Center, Beijing Hotgen Biotech Co. Ltd., Beijing, China.
Chundong YuState Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, China.
Yi HuangCenter for Experimental Research in Clinical Medicine, Fujian Provincial Hospital, Fuzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Early diagnosis is a major challenge in lung adenocarcinoma (LUAD). Tumor-derived exosomal microRNAs (miRNAs) are promising diagnostic biomarkers, and given the aberrant overexpression of tumor-associated glycans on exosomes, we employed a GlyExo-Capture approach using wheat germ agglutinin (WGA)- and lentil lectin (LCA)-coated magnetic beads to enrich glycosylated exosomes (WGA- and LCA-exosomes) from serum, and then detected exosomal miRNAs in 413 serum samples. Initially, small RNA sequencing was performed on a screening set (

Indexed as

biomarkersearly diagnosisGlyExo-Capture approachlung adenocarcinomaserum exosomal miRNA

Identifiers

PMID41451087
PMCPMC12727614

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.