Evidence map›Paper›PMID 41451080›Full record

ArticleFrontiers in medicine2025

Proteomics profiling of serum exosomes from azithromycin-sensitive and resistant

Huifeng Fan, Feng Huang, Chen Chen, Qiaoli Ren, Jing Zhou, Diyuan Yang, Gen Lu

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Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Huifeng FanDepartment of Respiration, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China.
Feng HuangGuangzhou Laboratory, The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China.
Chen ChenDepartment of Respiration, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China.
Qiaoli RenDepartment of Respiration, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China.
Jing ZhouDepartment of Respiration, Liuzhou Hospital, Guangzhou Women and Children's Medical Center, Liuzhou Guangxi, China.
Diyuan YangDepartment of Respiration, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China.
Gen LuDepartment of Respiration, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Methods: Serum samples were collected from Results: Distinct exosomal protein expression patterns were observed between AZM-sensitive and resistant patients. The HIF-1 and IL-17 signaling pathways were found to be associated with AZM resistance. Four proteins (KCTD12, LTF, TF, and MPO) were identified as potential biomarkers for distinguishing responders from non-responders. These biomarkers demonstrated over 80% sensitivity and 73.33% specificity in differentiating between the two groups. Conclusion: The study successfully identified four potential biomarkers (KCTD12, LTF, TF, and MPO) for AZM resistance in

Indexed as

azithromycin resistancediagnosisMycoplasma pneumoniaeproteomics profilingserum exosome

Identifiers

PMID41451080
PMCPMC12727566

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.