ArticleIndian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine
Varied Immunological Response to Test and Treat with Antiretroviral Therapy: A Longitudinal Study with Mixed Model Analysis.
Article in Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Clinical Characteristics and Treatment Outcomes among Tuberculosis and TB-HIV Coinfected Patients at Tertiary Health Care Center, South Gujarat, India: A Mixed-method Study.Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine · 2026Article
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Abstract
Background: The Test and Treat Policy (2017) of antiretroviral therapy (ART) was launched in India to achieve treatment goals more effectively than previous strategies. The study aimed to establish association of sociodemographic and clinical characteristics with immunological response to ART among patients living with HIV/AIDS (PLHIV) initiated on ART under the Test and Treat policy. Material and Methods: It was a longitudinal study conducted in a tertiary care hospital of South Gujarat, India, where data were collected from 318 PLHIV newly initiated on ART in 2018-19 regarding baseline and subsequent clinical (CD4 count, adherence, opportunistic infections, side effects) profiles. Association of these variables with CD4 count changes overtime was examined using repeated measures correlation and mixed models analysis. Results: Participants (63.2%) had a baseline CD4 count of less than 350 cells/cu.mm. Repeated measures correlation with adherence and rise in CD4 was significant in participants with baseline CD4 of 301-500 cells/cu.mm (ρ = 0.280, Conclusion: Lower baseline CD4 was not associated with significant rise despite early ART initiation. Significantly higher CD4 rise was seen in females. The majority of PLHIV were symptomatic with low baseline CD4. This opens the avenue for strengthening HIV/STI testing services for early detection and bidirectional screening.
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