ArticleInfection and drug resistance2025
Economic Burden of Carbapenem-Resistant Organisms in Critically Ill Patients: A Multicenter, Retrospective Cohort Study.
Article in Infection and drug resistance, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Efficacy and safety of ceftazidime-avibactam in carbapenem-resistant gram-negative bacilli sepsis according to infection site.American journal of translational research · 2026Article
- Risk Factors and Medical Burden of Multidrug-Resistant Organism Infection in Hospitalized Patients with Pneumonia.Infection and drug resistance · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Carbapenem-resistant organisms (CROs) are a growing threat in intensive care units (ICUs) worldwide due to the limited treatment options and high risk of morbidity and mortality. While previous studies have assessed the clinical implications of CROs, few have systematically quantified their economic burden. Aim: This study aimed to evaluate the economic burden attributable to CROs compared with carbapenem-susceptible organisms (CSOs) among critically ill patients in China. Methods: We conducted a retrospective cohort study including 7,232 ICU patients from two tertiary hospitals in Western China (2019-2024). Patients were assigned to either the CRO group or the CSO group and matched using a 1:1 propensity score matching (PSM) approach. ICU length of stay (LOS), hospital LOS, and total hospitalization cost were compared between the two groups, followed by generalized linear models (GLMs) to assess the independent impact of CRO status. Institutional-level opportunity costs were estimated based on excess ICU occupancy. Results: Among the 7,232 patients, 379 (5.24%) developed CRO, with carbapenem-resistant Acinetobacter baumannii (CRAB) being the predominant pathogen. PSM produced 379 pairs of CRO and CSO patients. The CRO group had significantly longer ICU LOS (median 11.0 vs 5.0 days, Conclusion: CROs are associated with substantially increased economic burden in ICU patients. These findings support the implementation of early screening, targeted prevention, and stewardship strategies to mitigate the impact of CROs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.