ReviewPakistan journal of medical sciences2025
Impact of chromosomal polymorphisms on pregnancy outcomes after in vitro fertilization or intracytoplasmic sperm injection: A systematic review and meta-analysis.
Review in Pakistan journal of medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- The Potential Role of Chromosomal Polymorphic Variations Attributed to Male Infertility: A Retrospective Cohort Study.Journal of reproduction & infertility · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Chromosomal polymorphisms (CPs), subtle variations in chromosome structure, have been previously reported in individuals with infertility, particularly among men. This systematic review and meta-analysis aim to analyze associations between CPs and pregnancy outcomes, focusing on spontaneous abortion rates. Methodology: A comprehensive literature search was conducted across three databases Medline, Google Scholar and Science Direct databases from inception to December 2023 for articles reporting the impact of CPs on selected fertilization and pregnancy outcomes among men/women/couples who had sought assisted reproductive technologies [ART; either Results: From an initial 4271 articles, 16 studies met the inclusion criteria. The analysis evaluated CPs in relation to reproductive outcomes, including abortion rates (AR), fertilization rates (FR), cleavage rates (CR), clinical pregnancy rates (CPR), and good-quality embryo rates (GQER). No significant associations were observed between CPs and AR across men, women, or couples, though high heterogeneity suggested variability in study populations. CPs were associated with a modest reduction (7%) in FR (RR 0.93, 95% CI 0.88-0.97, I2 = 67.8; P-value = 0.04), and GQER (RR 0.93, 95% CI 0.89-0.96, I2 = 17.4; P-value = 0.30), and a small but statistically significant reduction CRs (RR 0.98, 95% CI 0.97-0.99, I2 = 0.0; P-value = 0.48). Conclusions: The study highlights the influence of CPs on certain fertilization and pregnancy outcomes, particularly GQER, FR and CR, while their impact on miscarriage and clinical pregnancy outcomes remains inconclusive. Further large-scale studies are necessary to investigate further associations.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.