ArticleFrontiers in neuroscience2025
Characteristic of cerebral hemodynamics and functional connectivity in patients with neuropathic pain after spinal cord injury: an exploratory study.
Article in Frontiers in neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: This study investigated the brain functional characteristics of patients with neuropathic pain (NP) following spinal cord injury (SCI) using functional near-infrared spectroscopy (fNIRS). Methods: A total of 35 subjects were enrolled, including 10 able-bodied controls, 12 patients with SCI and NP (SCI-NP), and 13 patients with SCI (without NP). fNIRS was used to detected blood oxygen signals during motor tasks and resting-state (RS) functional connectivity (FC) in the subjects. We also performed Pearson correlation analyses of pain scores (NPS) and the Pittsburgh Sleep Quality Index (PSQI) in patients with SCI-NP. Statistical analyses were performed using Shapiro-Wilk test for normality; paired Results: During the task state, patients with SCI-NP activated bilateral primary somatosensory cortex (S1, L/R Conclusion: Patients with SCI-NP exhibit significant abnormal cerebral cortical excitation and reduced FC. HbO is a potential biomarker for evaluating NP. fNIRS supports objective assessment of SCI-NP and rehabilitation strategy formulation [ChiCTR2500097098].
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