ArticleFrontiers in microbiology2025
Analytical performance of the Xpert Carba-R assay for direct detection of carbapenemase genes in respiratory specimens from hospitalized patients: a multicenter evaluation in China.
Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Respiratory tract infections remain the main sites of carbapenem-resistant Methods: Respiratory specimens from hospitalized patients clinically diagnosed with pneumonia from seven tertiary hospitals in China from October 2022 to November 2023 were included. The CRE enzyme genes in specimens were directly detected and genotyped by using the Carba-R assay. Carbapenem resistance and genotypes were compared to a referee in combination of phenotypical and genotypical analyses of pure cultures recovered from the respiratory specimen. The CRE enzyme subtypes in isolates were determined by the WGS. Results: A total of 433 respiratory specimens were collected and tested in this study. The Carba-R assay detected 180 Conclusion: The Carba-R assay satisfactorily detected and identified carbapenemase genes directly in the respiratory specimens. A variety of CRE enzyme genotypes and subtypes were identified in respiratory specimens especially the Northwest region of China.
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