Evidence map›Paper›PMID 41450931›Full record

ArticleFrontiers in oncology2025

Metachronous multicentric giant cell tumor of bone treated with denosumab and mega-prosthesis revision: a rare case report.

Huaitai Lin, Chanping Yang, Jinhao Zhu, Chenyu Yang, Zijian Xu, Zejin Wu, Xinjia Wang, Weidong Wang

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Huaitai Lin *Orthopedics Department, Cancer Hospital of Shantou University Medical College, Shantou, Guangdong, China.
Chanping Yang *Operating Room, Cancer Hospital of Shantou University Medical College, Shantou, Guangdong, China.
Jinhao Zhu *Orthopedics Department, Cancer Hospital of Shantou University Medical College, Shantou, Guangdong, China.
Chenyu YangOrthopedics Department, Cancer Hospital of Shantou University Medical College, Shantou, Guangdong, China.
Zijian XuOrthopedics Department, Cancer Hospital of Shantou University Medical College, Shantou, Guangdong, China.
Zejin WuOrthopedics Department, Cancer Hospital of Shantou University Medical College, Shantou, Guangdong, China.
Xinjia WangOrthopedics Department, Cancer Hospital of Shantou University Medical College, Shantou, Guangdong, China.
Weidong WangOrthopedics Department, Cancer Hospital of Shantou University Medical College, Shantou, Guangdong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Multicentric giant cell tumor of bone is extremely rare, accounting for less than 1% of all giant cell tumor of bone (GCTB) cases. Metachronous multicentric GCTB is even rarer. Case presentation: We present a rare case of metachronous multicentric giant cell tumor of bone (GCTB) in a 27-year-old male, in whom three distinct lesions developed sequentially over a 10-year period: first in the right distal femur, followed by the proximal femur, and later the proximal tibia. To address progressive disease and prosthetic complications, the patient underwent revision of the mega-prosthesis combined with adjuvant denosumab therapy, followed by curettage of the subsequently emerging tibial lesion. Conclusion: This case illustrates the sequential development of multiple GCTB lesions and the importance of combined surgical reconstruction and denosumab therapy in long-term management.

Indexed as

curettagedenosumabmega-prosthesismetachronous multicentric GCTBmulticentric giant cell tumor

Identifiers

PMID41450931
PMCPMC12727548

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.