Evidence map›Paper›PMID 41450906›Full record

ArticleRespiratory medicine case reports2025

Pycnodysostosis and obstructive sleep apnea: Observations on 10 cases.

Abir Bouhamdi, David Gozal, Yassin Chefchaou, Meryem Benjelloun, Sanae Labyad, Abdellah Abida, Sana Abourazzak, Zouhayr Souirti, Mounia Serraj, Amara Bouchra and 2 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Respiratory medicine case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Abir BouhamdiSleep Medicine Center, Hassan II University Hospital, Laboratory of Epidemiology and Health Sciences Research, Sidi Mohamed Ben Abdellah University, PO Box: 1835, Route Sidi Harazem, 30050, Fez, Morocco.
David GozalOffice of The Dean and Department of Pediatrics, Joan C. Edwards School of Medicine, Marshall University, 1600 Medical Center Dr, Huntington, WV, 25701, United States of America.
Yassin ChefchaouSleep Medicine Center, Hassan II University Hospital, Laboratory of Epidemiology and Health Sciences Research, Sidi Mohamed Ben Abdellah University, PO Box: 1835, Route Sidi Harazem, 30050, Fez, Morocco.
Meryem BenjellounSleep Medicine Center, Hassan II University Hospital, Laboratory of Epidemiology and Health Sciences Research, Sidi Mohamed Ben Abdellah University, PO Box: 1835, Route Sidi Harazem, 30050, Fez, Morocco.
Sanae LabyadSleep Medicine Center, Hassan II University Hospital, Laboratory of Epidemiology and Health Sciences Research, Sidi Mohamed Ben Abdellah University, PO Box: 1835, Route Sidi Harazem, 30050, Fez, Morocco.
Abdellah AbidaSleep Medicine Center, Hassan II University Hospital, Laboratory of Epidemiology and Health Sciences Research, Sidi Mohamed Ben Abdellah University, PO Box: 1835, Route Sidi Harazem, 30050, Fez, Morocco.
Sana AbourazzakDepartment of Pediatrics, Hassan II University Hospital, Sidi Mohamed Ben Abdellah University, PO Box: 1835, Route Sidi Harazem, 30050, Fez, Morocco.
Zouhayr SouirtiSleep Medicine Center, Hassan II University Hospital, Laboratory of Epidemiology and Health Sciences Research, Sidi Mohamed Ben Abdellah University, PO Box: 1835, Route Sidi Harazem, 30050, Fez, Morocco.
Mounia SerrajDepartment of Pulmonology, Hassan II University Hospital, Laboratory of Epidemiology and Health Sciences Research, Sidi Mohamed Ben Abdellah University, PO Box: 1835, Route Sidi Harazem, 30050, Fez, Morocco.
Amara BouchraDepartment of Pulmonology, Hassan II University Hospital, Laboratory of Epidemiology and Health Sciences Research, Sidi Mohamed Ben Abdellah University, PO Box: 1835, Route Sidi Harazem, 30050, Fez, Morocco.
Mohamed Chakib BenjellounDepartment of Pulmonology, Hassan II University Hospital, Laboratory of Epidemiology and Health Sciences Research, Sidi Mohamed Ben Abdellah University, PO Box: 1835, Route Sidi Harazem, 30050, Fez, Morocco.
Mohammed ELBiazeSleep Medicine Center, Hassan II University Hospital, Laboratory of Epidemiology and Health Sciences Research, Sidi Mohamed Ben Abdellah University, PO Box: 1835, Route Sidi Harazem, 30050, Fez, Morocco.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Pycnodysostosis is a rare skeletal disorder often associated with craniofacial anomalies that may increase the propensity for obstructive sleep apnea (OSA). This retrospective study aimed to explore the prevalence and treatment of OSA in pediatric patients with Pycnodysostosis. Objectives: To describe the clinical characteristics, polysomnographic findings, and treatment in 10 children with Pycnodysostosis. Methods: Retrospective study conducted at the Sleep Medicine Center of CHU Hassan II, Fès, Morocco of 10 children with Pycnodysostosis diagnosed between 2010 and 2024 and based on clinical and/or genetic criteria who underwent overnight polysomnography. Results: All patients suffered from moderate to severe OSA (apnea-hypopnea index: 5.9-43.8 events/h). Treatment included adenoidectomy, tonsillectomy, and CPAP, the latter leading to near normalization of respiratory patterns and improvement in sleep quality. Conclusion: OSA in Pycnodysostosis imposes a significant impact on quality of life which responds favorably to stepwise interventions aimed at eliminating or mitigating OSA severity. This study highlights the importance of early diagnosis and appropriate treatment to prevent long-term complications, especially involving maxillofacial growth.

Indexed as

Continuous positive airway pressure (CPAP)ENT abnormalitiesFacial dysmorphiaMaxillofacial growthMultidisciplinary treatmentObstructive sleep apnea syndrome (OSA)PediatricsPolysomnographyPycnodysostosisSleep disorders

Identifiers

PMID41450906
PMCPMC12731286

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.