Evidence map›Paper›PMID 41450897›Full record

ArticleACG case reports journal2026

Heterotopic Ossification in an Appendiceal Sessile Serrated Lesion With Synchronous Neuroendocrine Tumor.

Paul J Wurtz, Douglas Walton, Calen Gist, Devin Moore, Serena Murphy, Carl Kay

Abstract readCase Reports
In one paragraph

Article in ACG case reports journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Paul J WurtzDepartment of Internal Medicine, Brooke Army Medical Center, San Antonio, TX.ORCID https://orcid.org/0000-0002-0071-3401
Douglas WaltonDepartment of Pathology, Brooke Army Medical Center, San Antonio, TX.
Calen GistDepartment of Surgery, Brooke Army Medical Center, San Antonio, TX.
Devin MooreDepartment of Internal Medicine, Brooke Army Medical Center, San Antonio, TX.
Serena MurphyDepartment of Surgery, Brooke Army Medical Center, San Antonio, TX.
Carl KayDepartment of Gastroenterology, Carl R. Darnall Army Medical Center, Fort Hood, TX.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Heterotopic ossification (HO) in colorectal polyps is rare and scarcely reported in serrated lesions. We report an appendiceal sessile serrated lesion (SSL) with mature bone and a contiguous well-differentiated neuroendocrine tumor. A 64-year-old woman had a firm appendiceal-orifice polyp biopsied in 2012 showing calcification; SSL was identified in 2019. In 2024, an 8-mm lesion was removed en bloc by underwater cold snare; histology showed SSL with HO. Laparoscopic appendectomy confirmed residual SSL with HO and an adjacent 4.5-mm grade-1 neuroendocrine tumor (INSM1+, Ki-67 <3%) with negative margins. HO recognition should prompt en bloc excision and attentive pathology.

Indexed as

appendiceal orificecolorectal polypheterotopic ossificationneuroendocrine tumorosseous metaplasiasessile serrated lesionunderwater cold snare

Identifiers

PMID41450897
PMCPMC12737857

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.