Evidence map›Paper›PMID 41450858›Full record

ReviewJournal of pharmaceutical analysis2025

Advancements in plant-derived exosome-like vesicles: Versatile bioactive carriers for targeted drug delivery systems.

Haixia Shen, Shuaiguang Li, Liyuan Lin, Qian Wu, Zhonghua Dong, Wei Xu

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of pharmaceutical analysis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Haixia ShenSchool of Pharmacy, The Shandong Second Medical University, Weifang, Shandong, 261053, China.
Shuaiguang LiDepartment of Oncology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Lung Cancer Institute, Jinan, 250014, China.
Liyuan LinSchool of Pharmacy, The Shandong Second Medical University, Weifang, Shandong, 261053, China.
Qian WuSchool of Pharmacy, The Shandong Second Medical University, Weifang, Shandong, 261053, China.
Zhonghua DongDepartment of Clinical Pharmacy, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, 250014, China.
Wei XuSchool of Pharmacy, The Shandong Second Medical University, Weifang, Shandong, 261053, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exosomes, small vesicles secreted by a wide range of cells, are found extensively in animals, plants, and microorganisms. Their excellent biocompatibility, efficient delivery capacity, and ease of membrane crossing have drawn significant interest as promising drug delivery carriers. Compared with their animal-derived counterparts, plant-derived exosomes (PDEs), in particular, stand out for their lower toxicity to human tissues, diverse sources, and enhanced targeted delivery capabilities. Advances in both in-depth research and technological development have enabled scholars to isolate exosomes successfully from various plants, exploring their potential in clinical therapies. However, the precise identification of PDEs and their drug delivery mechanisms remains an area of ongoing investigation. This review synthesizes the latest developments in the biogenesis, extraction, separation, and identification of PDEs, along with their engineering modifications and drug-loading strategies. We also delve into the therapeutic applications of exosomes and their future potential in drug delivery, aiming to elucidate the targeted delivery mechanisms of PDEs and pave new paths for clinical drug treatment.

Indexed as

Delivery of drugsExtracellular vesiclesNanocarriersNanoparticlesPlant-derived exosomes

Identifiers

PMID41450858
PMCPMC12731909

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.