Evidence map›Paper›PMID 41450786›Full record

Article3 Biotech2025

Enhanced production of methylated resveratrol in engineered

Nguyen Quang Huy, Quyen My Linh, Nguyen Thi An Hoa, Do Minh Ha, Tran Van Tuan, Luan Luong Chu

Abstract read
In one paragraph

Article in 3 Biotech, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Nguyen Quang HuyNational Key Laboratory of Enzyme and Protein Technology, University of Science, Vietnam National University, Hanoi (VNU), 334 Nguyen Trai, Thanh Xuan, Hanoi, 10000 Vietnam.
Quyen My LinhNational Key Laboratory of Enzyme and Protein Technology, University of Science, Vietnam National University, Hanoi (VNU), 334 Nguyen Trai, Thanh Xuan, Hanoi, 10000 Vietnam.
Nguyen Thi An HoaFaculty of Biology, University of Science, Vietnam National University, Hanoi (VNU), 334 Nguyen Trai, Thanh Xuan, Hanoi, 10000 Vietnam.
Do Minh HaNational Key Laboratory of Enzyme and Protein Technology, University of Science, Vietnam National University, Hanoi (VNU), 334 Nguyen Trai, Thanh Xuan, Hanoi, 10000 Vietnam.
Tran Van TuanNational Key Laboratory of Enzyme and Protein Technology, University of Science, Vietnam National University, Hanoi (VNU), 334 Nguyen Trai, Thanh Xuan, Hanoi, 10000 Vietnam.
Luan Luong ChuNational Key Laboratory of Enzyme and Protein Technology, University of Science, Vietnam National University, Hanoi (VNU), 334 Nguyen Trai, Thanh Xuan, Hanoi, 10000 Vietnam.ORCID 0000-0001-9223-6798

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Resveratrol, a prominent member of the plant-derived stilbenoid family, exhibits diverse biological and pharmaceutical activities. Its methylated derivatives possess enhanced attributes compared to the parent compound, such as improved stability and bioavailability. Although resveratrol analogs are widely used in healthcare and industrial applications, their current production relies predominantly on plant extraction, which often leads to low yields and inconsistent product quality. Microbial biosynthesis offers a promising alternative to chemical synthesis and plant-based extraction. Furthermore, gene expression regulation of engineered microbes allows cells to respond to their environment and maintain proper cellular function, which results in improved target products. In this study, we developed synthetic gene clusters comprising Supplementary Information: The online version contains supplementary material available at 10.1007/s13205-025-04449-5.

Indexed as

4′-O-methylresveratrolAnticancer activityE. coliMethyltransferaseResveratrol

Identifiers

PMID41450786
PMCPMC12728154

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.