Evidence map›Paper›PMID 41450756›Full record

ArticleEnvironmental epidemiology (Philadelphia, Pa.)2026

Individual and combined effects of indoor home exposures and ambient PM

Akihiro Shiroshita, Antonella Zanobetti, Brent A Coull, Patrick H Ryan, Soma Datta, Jeffrey Blossom, Emily Oken, James E Gern, Heike Luttmann-Gibson, Eneida A Mendonça and 15 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental epidemiology (Philadelphia, Pa.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Akihiro ShiroshitaDivision of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.ORCID https://orcid.org/0000-0003-0262-459X
Antonella ZanobettiDepartment of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.
Brent A CoullDepartment of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.
Patrick H RyanDepartment of Pediatrics, University of Cincinnati, College of Medicine, Cincinnati, Ohio.
Soma DattaChanning Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
Jeffrey BlossomCenter for Geographic Analysis, Harvard University, Cambridge, Massachusetts.
Emily OkenDepartment of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts.
James E GernDepartment of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
Heike Luttmann-GibsonDepartment of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.
Eneida A MendonçaDivision of Biomedical Informatics, Cincinnati Children's Hospital Medical Center and University of Cincinnati, Cincinnati, Ohio.
Sima K RamratnamDepartment of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
Sheryl L Rifas-ShimanDepartment of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts.
Joanne E SordilloDepartment of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts.
Veronica A WangDepartment of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.
Paloma I BeamerAsthma and Airways Disease Research Center, University of Arizona, Tucson, Arizona.
Daniel J JacksonDepartment of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
Christine C JohnsonDepartment of Public Health Sciences, Henry Ford Health, Detroit, Michigan.
Gurjit K Khurana HersheyDepartment of Pediatrics, University of Cincinnati, College of Medicine, Cincinnati, Ohio.
Fernando D MartinezAsthma and Airways Disease Research Center, University of Arizona, Tucson, Arizona.
Rachel L MillerDivision of Clinical Immunology, Icahn School of Medicine at Mount Sinai, New York, New York.
Katherine Rivera-SpoljaricDepartment of Pediatrics, Washington University School of Medicine, St. Louis, Missouri.
Edward M ZorattiDivision of Allergy and Clinical Immunology, Department of Internal Medicine, Henry Ford Health, Detroit, Michigan.
Tina V HartertDivision of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.
Diane R GoldDepartment of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.
ECHO Cohort Consortium

Funding

Project-005U2COD023375 · OD · DUKE UNIVERSITY · PI Phillip Brian Smith · 2016 to 2026
$215.9M
ECHODAC (Environmental Influences on Child Health Outcomes Data Analysis Center)U24OD023382 · OD · JOHNS HOPKINS UNIVERSITY · PI Diane J Catellier, LISA P JACOBSON · 2016 to 2026
$148.4M
Vanderbilt Institute for Clinical and Translational Research (VICTR) -Identifying correlates of functional immunity in SARS-CoV-2 convalescent plasmaUL1TR002243 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Paul A. Harris, Wesley H Self · 2017 to 2026
$130.7M
Mount Sinai ECHO site for Perinatal Environment and Development StudiesUH3OD023337 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KECIA Nicole CARROLL, Robert O Wright · 2018 to 2026
$54.1M
Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI JAIME ELIZABETH HART · 1985 to 2026
$44.6M
Translational Research Support CoreP30ES013508 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI A. Clementina Mesaros · 2006 to 2026
$35.3M
Viral and Host Determinants of Infant and Childhood Allergy and AsthmaU19AI095227 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Tina V Hartert · 2011 to 2026
$34.9M
The Effect of Dog-Keeping and the Intestinal Microbiota on Immune DevelopmentP01AI089473 · NIAID · HENRY FORD HEALTH SYSTEM · PI LUKACS, NICHOLAS W · 2012 to 2024
$25.7M
Utah Children's ProjectUH3OD023249 · OD · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Christina Porucznik, JOSEPH BARNEY STANFORD · 2018 to 2026
$17.7M
Common and distinct early environmental influences on cardiometabolic and respiratory health: Mechanisms and methodsUH3OD023286 · OD · HARVARD PILGRIM HEALTH CARE, INC. · PI OKEN, EMILY · 2018 to 2022
$11.7M
Pilot Project ProgramP30ES020957 · NIEHS · WAYNE STATE UNIVERSITY · PI RUNGE-MORRIS, MELISSA A · 2014 to 2021
$10.1M
Utah Children's ProjectUG3OD023249 · OD · UNIVERSITY OF UTAH · PI PORUCZNIK, CHRISTINA, STANFORD, JOSEPH BARNEY · 2016 to 2024
$9.4M
NCATS NIH HHS UL1 TR002243NIAID NIH HHS P01 AI089473NIAID NIH HHS U19 AI095227NIAID NIH HHS U24 AI179612NIEHS NIH HHS P30 ES000002NIEHS NIH HHS P30 ES013508NIEHS NIH HHS P30 ES020957NIH HHS U24 OD023382NIH HHS U2C OD023375NIH HHS UG3 OD023249NIH HHS UG3 OD035516NIH HHS UG3 OD035517NIH HHS UG3 OD035518NIH HHS UG3 OD035533NIH HHS UH3 OD023249NIH HHS UH3 OD023286NIH HHS UH3 OD023337NIH HHS UH3 OD035516NIH HHS UH3 OD035518
6 · The paper itself

Abstract

Background: Children encounter multiple indoor and outdoor environmental exposures in early life. We assessed the independent effects of indoor home exposures and ambient particulate matter with an aerodynamic diameter ≤2.5 µm (PM Methods: We included 6,413 children born 1987-2016 from nine United States prospective birth cohorts from the Environmental Influences on Child Health Outcomes consortium, with complete covariate and outcome data. Exposures were (1) average ambient PM Results: By age 5 years, 10.3%-50.3% of children had developed asthma across general-risk and high-risk cohorts. We found a significant detrimental association of PM Conclusion: Multiple early exposures, such as PM

Indexed as

Air pollutionAsthmaChildhood asthmaPetsPM2.5Water damage/home dampness

Identifiers

PMID41450756
PMCPMC12737862

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.