ReviewFrontiers in cell and developmental biology2025
Stem cell-based strategies for intervertebral disc regeneration in degenerative microenvironments: challenges and solutions.
Review in Frontiers in cell and developmental biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Low back pain (LBP) is a common musculoskeletal disorder, and its pathological basis is closely related to intervertebral disc degeneration (IVDD). Although commonly used conservative treatments and surgical interventions can alleviate symptoms, they are difficult to fundamentally delay or reverse the process of IVDD. In recent years, biological treatment strategies centered on cell therapy, targeting the initiating mechanisms of IVDD, have provided new directions for the fundamental treatment of this disease. Among them, mesenchymal stem cells (MSCs) are regarded as ideal candidate cell types for achieving intervertebral disc regeneration due to their immunomodulatory properties and multidifferentiation potential. The discovery of endogenous stem cells within the intervertebral disc further reveals the tissue's own repair potential. As the "soil" upon which "seed" cells depend for survival, the intervertebral disc microenvironment, composed of cell niches and their surrounding biochemical and physical factors, plays a key regulatory role in the proliferation, differentiation, and functional expression of stem cells and endogenous cells. However, the intervertebral disc is naturally in extreme conditions such as low oxygen, low nutrition, acidic pH, and high mechanical load. This microenvironment further deteriorates during the degeneration process, not only severely affecting the survival and function of resident cells but also posing severe challenges for stem cell transplantation therapy. This article systematically reviews the characteristics of the intervertebral disc microenvironment under physiological and degenerative states, focusing on the impact of the degenerative microenvironment on the biological behavior of stem cells. It summarizes key strategies for enhancing MSC adaptability and therapeutic efficacy and proposes standardized parameters for optimizing clinical applications, aiming to provide a theoretical basis and path support for advancing the clinical translation of stem cell therapy in intervertebral disc regeneration.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.