Evidence map›Paper›PMID 41450668›Full record

ArticleJACS Au2025

Discovery of d‑Miniprotein Inhibitors of PD-1/PD-L1 Interaction via Mirror-Image Phage Display against Synthetic d‑PD‑1.

Haiyan Zhou, Hongxiang Wu, Zhixiang Zhong, Pilar Blasco, Jingwen Zeng, Jiaqi Wang, Han Liu, Xuechen Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACS Au, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Haiyan ZhouChemistry and Chemical Engineering Guangdong Laboratory, Shantou, Guangdong, P. R. China 515063.
Hongxiang WuDepartment of Chemistry, State Key Laboratory of Synthetic Chemistry, The University of Hong Kong, Hong Kong SAR, P. R. China 999077.ORCID https://orcid.org/0009-0009-1437-7689
Zhixiang ZhongChemistry and Chemical Engineering Guangdong Laboratory, Shantou, Guangdong, P. R. China 515063.
Pilar BlascoDepartment of Chemistry, State Key Laboratory of Synthetic Chemistry, The University of Hong Kong, Hong Kong SAR, P. R. China 999077.ORCID https://orcid.org/0000-0001-6703-5417
Jingwen ZengDepartment of Chemistry, State Key Laboratory of Synthetic Chemistry, The University of Hong Kong, Hong Kong SAR, P. R. China 999077.
Jiaqi WangDepartment of Chemistry, State Key Laboratory of Synthetic Chemistry, The University of Hong Kong, Hong Kong SAR, P. R. China 999077.ORCID https://orcid.org/0000-0002-5045-1497
Han LiuDepartment of Chemistry, State Key Laboratory of Synthetic Chemistry, The University of Hong Kong, Hong Kong SAR, P. R. China 999077.ORCID https://orcid.org/0000-0003-1412-4584
Xuechen LiDepartment of Chemistry, State Key Laboratory of Synthetic Chemistry, The University of Hong Kong, Hong Kong SAR, P. R. China 999077.ORCID https://orcid.org/0000-0001-5465-7727

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As a member of the immune checkpoint, PD-1 is acknowledged as a key player in immune regulation and a hot target for cancer immunotherapy. The broad and flat binding interface of PD-1 to PD-L1 poses a challenge to non-antibody inhibitor discovery. In this work, through mirror-image phage display, we developed the first d-miniprotein inhibitor of PD-1/PD-L1 interaction,

Indexed as

miniproteinmirror-image phage displaynon-antibody inhibitorPD-1/PD-L1 inhibitionprotein−protein interaction

Identifiers

PMID41450668
PMCPMC12728642

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.