Evidence map›Paper›PMID 41450663›Full record

ArticleJACS Au2025

Regioselective Glycosylation of Fluorine-18-Labeled Sorbitol for Enhanced Bacterial Detection In Vivo Using PET.

Sang Hee Lee, Jung Min Kim, Marina López-Álvarez, Alexandre M Sorlin, Mohammad Yaqoob Bhat, Joseph Blecha, Robert R Flavell, Youngho Seo, Joanne Engel, Michael Ohliger and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACS Au, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sang Hee LeeDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California 94158, United States.ORCID https://orcid.org/0000-0001-8578-9968
Jung Min KimDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California 94158, United States.ORCID https://orcid.org/0009-0003-9492-510X
Marina López-ÁlvarezDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California 94158, United States.ORCID https://orcid.org/0000-0001-5794-5951
Alexandre M SorlinDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California 94158, United States.
Mohammad Yaqoob BhatDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California 94158, United States.ORCID https://orcid.org/0000-0002-0888-5603
Joseph BlechaDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California 94158, United States.
Robert R FlavellDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California 94158, United States.ORCID https://orcid.org/0000-0002-8694-1199
Youngho SeoDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California 94158, United States.
Joanne EngelDepartment of Medicine, University of California, San Francisco, San Francisco, California 94158, United States.
Michael OhligerDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California 94158, United States.
David M WilsonDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California 94158, United States.ORCID https://orcid.org/0000-0002-1095-046X

Funding

Development of 11C-PABA as a bacteria-specific imaging agent for spinal infectionsR01EB025985 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JAIN, SANJAY, WILSON, DAVID M · 2018 to 2021
$2.7M
Sensing living P. aeruginosa using D-alanine derived radiotracersR01EB030897 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ENGEL, JOANNE N., OHLIGER, MICHAEL · 2021 to 2024
$2.7M
ACE2-targeted PET radiotracers for investigating spatiotemporal distribution of SARS-CoV-2 organ injury and therapy response.R01AI161829 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DESAI, TEJAL A., FLAVELL, ROBERT RICHARD · 2021 to 2023
$2.4M
Chemoenzymatic radiosyntheses of [18F]FDG-derived oligosaccharides for S. aureus detectionR01AI181378 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Michael Ohliger, David M Wilson · 2024 to 2026
$2.3M
Clinical translation of D-amino acid derived PET tracers for imaging spinalinfectionR01EB024014 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI OHLIGER, MICHAEL, WILSON, DAVID M · 2017 to 2020
$2.2M
Imaging bacterial infection using deuterium-enriched sugar alcohols.R21AI164684 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WILSON, DAVID M · 2021 to 2022
$444k
NIAID NIH HHS R01 AI161829NIAID NIH HHS R01 AI181378NIAID NIH HHS R21 AI164684NIBIB NIH HHS R01 EB024014NIBIB NIH HHS R01 EB025985NIBIB NIH HHS R01 EB030897
6 · The paper itself

Abstract

Precise and rapid detection of bacterial infection in vivo remains a significant challenge in clinical practice. In response to this challenge, several pathogen-specific positron emission tomography (PET) tracers have been developed, including the fluorine-18-labeled sorbitol derivative [

Indexed as

18F-sugar alcoholbacteriaglycosylationinfection imagingpositron emission tomography

Identifiers

PMID41450663
PMCPMC12728616

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.