ArticleJACS Au2025
Nickel-Catalyzed Cross-Coupling of Aryl Chlorides by Heated Mechanochemistry: Scalable Suzuki-Miyaura Reactions via Twin-Screw Extrusion.
Article in JACS Au, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
The direct use of aryl chlorides in Suzuki-Miyaura cross-coupling remains a long-standing challenge due to the inert nature of the C-Cl bond. Herein, we report the first nickel-catalyzed Suzuki-Miyaura cross-coupling of aryl chlorides under solvent-minimized, heated mechanochemical conditions. Employing liquid-assisted grinding (LAG) and thermal input, a broad range of electron-deficient and electron-rich aryl chlorides were successfully coupled with aryl boronic acids in under 1 h. The methodology was translated to a twin-screw extrusion (TSE) process, enabling continuous production at scales up to 400 mmol and 65 g isolated product. This work demonstrates a sustainable, scalable strategy for C-C bond formation using readily available feedstocks, highlighting the synergy between nickel catalysis, mechanochemistry, and continuous flow processing.
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