Evidence map›Paper›PMID 41450638›Full record

ArticleJACS Au2025

Protonated Phenanthroline Catalyzed Stereoselective Glycosylation: Synthesis and Evaluation of Saponin Adjuvant Lablaboside F and Variants Leading to Simplified Vaccine Adjuvants.

Jayanta Ghorai, Austin B Santhin, Leila Almounajed, Stacey M Hartwig, Steven M Varga, Hien M Nguyen

Abstract read
In one paragraph

Article in JACS Au, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jayanta GhoraiDepartment of Chemistry, Wayne State University, Detroit, Michigan 48202, United States.ORCID https://orcid.org/0000-0001-6339-3575
Austin B SanthinGraduate School of Biomedical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, United States.
Leila AlmounajedDepartment of Chemistry, Wayne State University, Detroit, Michigan 48202, United States.ORCID https://orcid.org/0000-0002-2718-8299
Stacey M HartwigDepartment of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, United States.
Steven M VargaGraduate School of Biomedical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, United States.
Hien M NguyenDepartment of Chemistry, Wayne State University, Detroit, Michigan 48202, United States.ORCID https://orcid.org/0000-0002-7626-8439

Funding

Tailoring Structures of Sulfated Oligosaccharides for Modulating Heparanase ActivityR01GM098285 · NIGMS · WAYNE STATE UNIVERSITY · PI NGUYEN, HIEN M · 2012 to 2022
$3.5M
Synthesis and Evaluation of Carbohydrate Vaccine AdjuvantsR01AI169505 · NIAID · WAYNE STATE UNIVERSITY · PI NGUYEN, HIEN M, VARGA, STEVEN M · 2022 to 2025
$3.2M
500 MHz NMR SpectrometerS10OD028488 · OD · WAYNE STATE UNIVERSITY · PI ALLEN, MATTHEW J · 2021 to 2021
$600k
NIAID NIH HHS R01 AI169505NIGMS NIH HHS R01 GM098285NIH HHS S10 OD028488
6 · The paper itself

Abstract

Vaccine adjuvants are substances that are coadministered with antigens to enhance the immune response. Lablaboside F, a triterpene oleanolic acid β-linked to two trisaccharide chains on its eastern and western sides, emerged as a promising adjuvant candidate due to exhibiting robust adjuvanticity and low toxicity . We developed a β-stereoselective glycosylation method using a [PhenH]

Indexed as

C2-branched oligosaccharideoleanolic acidorganocatalystsaponinstereoselective glycosylationtrichloroacetimidatevaccine adjuvant

Identifiers

PMID41450638
PMCPMC12728621

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.