Palladium-Catalyzed Regio- and Stereoselective C-H Alkynylation of Conjugated Dienols.

Meng-Wei Yang, Huan-Xuan Lu, Jun-Wei Zhang, Yun-He Xu

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Article in JACS Au, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 authors.

Meng-Wei YangDepartment of Chemistry, University of Science and Technology of China, Hefei 230026, P. R. China.

Huan-Xuan LuDepartment of Chemistry, University of Science and Technology of China, Hefei 230026, P. R. China.

Jun-Wei ZhangDepartment of Chemistry, University of Science and Technology of China, Hefei 230026, P. R. China.

Yun-He XuDepartment of Chemistry, University of Science and Technology of China, Hefei 230026, P. R. China.ORCID https://orcid.org/0000-0001-8817-0626

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6 · The paper itself

Abstract

The regioselective activation of alkenyl C-H bonds in conjugated dienols presents significant challenges due to the presence of multiple similarly reactive sites. In this study, we developed a palladium-catalyzed alkynylation method that is both regio- and stereoselective for the activation of internal alkenyl C-H bonds. This approach provides an efficient and versatile strategy for synthesizing dienyne derivatives with precise

Indexed as

C−H ActivationConjugated DienynesHeck ReactionRegioselectivityStereoswitchable

Identifiers

PMID41450634

DOI10.1021/jacsau.5c01417

PMCPMC12728612

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