Evidence map›Paper›PMID 41450588›Full record

ArticleProceedings of SPIE--the International Society for Optical Engineering2025

Scalable, reproducible, and cost-effective processing of large-scale medical imaging datasets.

Michael E Kim, Karthik Ramadass, Chenyu Gao, Praitayini Kanakaraj, Nancy R Newlin, Gaurav Rudravaram, Kurt G Schilling, Blake E Dewey, Derek Archer, Timothy J Hohman and 4 more

Abstract read
In one paragraph

Article in Proceedings of SPIE--the International Society for Optical Engineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
  2. Article
  3. The role of vascular risk factors in white matter tract microstructure: a multi-cohort study in older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  4. Article
  5. Genetic architecture of the limbic white matter microstructure in aging and Alzheimer's Disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Characterizing Continuous and Discrete Hybrid Latent Spaces for Structural Connectomes.Proceedings of SPIE--the International Society for Optical Engineering · 2026
    Article
  10. Article
  11. Article
  12. Analytic Bounds on GAMLSS Model Variability of Normative White Matter Brain Charts.Proceedings of SPIE--the International Society for Optical Engineering · 2026
    Article
  13. Modeling a Shared Reality of Tractography through Varied Structural Imaging.Proceedings of SPIE--the International Society for Optical Engineering · 2026
    Article
  14. Lifespan Trajectories of Asymmetry in White Matter Tracts.bioRxiv : the preprint server for biology · 2025
    Article
  15. Article
  16. Article
  17. The effect of Alzheimer's disease genetic factors on limbic white matter microstructure.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Michael E KimVanderbilt University, Department of Computer Science, Nashville, TN, USA.
Karthik RamadassVanderbilt University, Department of Computer Science, Nashville, TN, USA.
Chenyu GaoVanderbilt University, Department of Electrical and Computer Engineering, Nashville, TN, USA.
Praitayini KanakarajVanderbilt University, Department of Computer Science, Nashville, TN, USA.
Nancy R NewlinVanderbilt University, Department of Computer Science, Nashville, TN, USA.
Gaurav RudravaramVanderbilt University, Department of Electrical and Computer Engineering, Nashville, TN, USA.
Kurt G SchillingVanderbilt University Medical Center, Department of Radiology and Radiological Sciences, Nashville, TN, USA.
Blake E DeweyDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Derek ArcherVanderbilt University Medical Center, Vanderbilt Memory and Alzheimer's Center, Nashville, TN, USA.
Timothy J HohmanVanderbilt University Medical Center, Vanderbilt Memory and Alzheimer's Center, Nashville, TN, USA.
Zhiyuan LiVanderbilt University, Department of Electrical and Computer Engineering, Nashville, TN, USA.
Shunxing BaoVanderbilt University, Department of Electrical and Computer Engineering, Nashville, TN, USA.
Bennett A LandmanVanderbilt University, Department of Computer Science, Nashville, TN, USA.
Nazirah Mohd KhairiVanderbilt University, Department of Electrical and Computer Engineering, Nashville, TN, USA.

Funding

Vanderbilt Institute for Clinical and Translational Research (VICTR) -Identifying correlates of functional immunity in SARS-CoV-2 convalescent plasmaUL1TR002243 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Paul A. Harris, Wesley H Self · 2017 to 2026
$130.7M
The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
MVP Data Integration into the ADSP Phenotype Harmonization ConsortiumU24AG074855 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CUCCARO, MICHAEL L, HOHMAN, TIMOTHY J · 2021 to 2025
$37.5M
Ultrascale Machine Learning to Empower Discovery in Alzheimers Disease BiobanksU01AG068057 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Christos Davatzikos, Heng Huang · 2020 to 2026
$20.7M
Overall: Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center at VanderbiltP50HD103537 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Lea K Davis · 2020 to 2026
$10.3M
Controlling Quality and Capturing Uncertainty in Advanced Diffusion Weighted MRIR01EB017230 · NIBIB · VANDERBILT UNIVERSITY · PI LANDMAN, BENNETT A. · 2015 to 2024
$5.1M
Genetic Drivers of Resilience to Alzheimer's DiseaseR01AG059716 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HOHMAN, TIMOTHY J · 2018 to 2022
$4.4M
Microstructure and connectivity modeling from the cortex to the spinal cord in Multiple SclerosisK01EB032898 · NIBIB · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SCHILLING, KURT G · 2022 to 2025
$630k
Genetic Contributors to White Matter Microstructure in Aging and Alzheimer’s DiseaseK01AG073584 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ARCHER, DEREK B · 2021 to 2025
$601k
High-Performance Computer Cluster for Biomedical ResearchS10OD023680 · OD · VANDERBILT UNIVERSITY · PI MEILER, JENS · 2017 to 2017
$587k
GPU-Accelerated Parallel Computer for Drug Discovery ApplicationsS10OD020154 · OD · VANDERBILT UNIVERSITY · PI SMITH, JARROD ANSON · 2015 to 2015
$225k
NCATS NIH HHS UL1 TR000445NCATS NIH HHS UL1 TR002243NIA NIH HHS K01 AG073584NIA NIH HHS R01 AG059716NIA NIH HHS U01 AG068057NIA NIH HHS U24 AG074855NIBIB NIH HHS K01 EB032898NIBIB NIH HHS R01 EB017230NICHD NIH HHS P50 HD103537NIH HHS S10 OD020154NIH HHS S10 OD023680
6 · The paper itself

Abstract

Curating, processing, and combining large-scale medical imaging datasets from national studies is a non-trivial task due to the intense computation and data throughput required, variability of acquired data, and associated financial overhead. Existing platforms or tools for large-scale data curation, processing, and storage have difficulty achieving a viable cost-to-scale ratio of computation speed for research purposes, either being too slow or too expensive. Additionally, management and consistency of processing large data in a team-driven manner is a non-trivial task. We design a BIDS-compliant method for an efficient and robust data processing pipeline of large-scale diffusion-weighted and T1-weighted MRI data compatible with low-cost, high-efficiency computing systems. Our method accomplishes automated querying of data available for processing and process running in a consistent and reproducible manner that has long-term stability, while using heterogenous low-cost computational resources and storage systems for efficient processing and data transfer. We demonstrate how our organizational structure permits efficiency in a semi-automated data processing pipeline and show how our method is comparable in processing time to cloud-based computation while being almost 20 times more cost-effective. Our design allows for fast data throughput speeds and low latency to reduce the time for data transfer between storage servers and computation servers, achieving an average of 0.60 Gb/s compared to 0.33 Gb/s for using cloud-based processing methods. The design of our workflow engine permits quick process running while maintaining flexibility to adapt to newly acquired data.

Indexed as

AI ReadyBatch ProcessingInformaticsMRI

Identifiers

PMID41450588
PMCPMC12734404

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.